Review Incorporating Mouse Genome Mammalian Genome 12, 755–757 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s00335-001-4006 Thomas R. Insel Center for Behavioral Neuroscience, Emory University, 954 Gatewood Rd NE, Atlanta, Georgia 30322, USA Received: 15 June 2001 / Accepted: 19 June 2001 Recent developments in mouse genetics, along with current mu- of cases, discussants noted the frequency of gastrointestinal, sen- tagenesis programs for discovering genes involved in behaviorally sory and sleep disturbances in autism. Problems in this area of defined phenotypes, suggest that mouse studies may provide im- research are (a) selection of the sample of autistic patients from a portant clues for our understanding of autism. On December 4, syndrome with such clinical diversity; (b) small sample sizes of 2000, the National Institute of Mental Health (NIMH) and The most studies given this clinical diversity and the likely heteroge- Jackson Laboratory sponsored a meeting at The Jackson Labora- neity that underlies this syndrome, and (c) selection of an appro- tory in Bar Harbor, Maine to bring together experts in the clinical priate control group. For instance, K. Nelson (NINDS) described features of autism, mouse genetics, and mouse phenotyping. The her study of neonatal blood levels of several
Mammalian Genome – Springer Journals
Published: Feb 20, 2014
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