292 Mammalian Genome 8, Brief Data Reports Fig. 1. Genetic mapping of Rab20 on Genetics (IMEG), Kumamoto University School of Medicine, mouse Chr 8. Segregation of D8MiH, 2-2-1 Honjo, Kumamoto 860, Japan Rab20, and D8Mit4 on mouse Chr 8 in 93 [C57BL/6J-bg x (C57BL6J-bg x Received: 16 August 1996 / Accepted: 2 December 1996 CAST/EiJ)FI] intersubspecific backcross DSMitl mice. Closed boxes represent the homo- Ra 20 m mDm Species: Mouse zygous B6 pattern, and open boxes the F1 DSMit4 m mmG Locus name: orthodenticle-related homeobox-2 pattern. Numbers of mice of each haplo- Locus symbol: Otx2 #of mice 39 51 1 1 1 type are indicated. Map position: centromere-D14Mit3-8.4 cM-Otx2, D14Mit101- 4.5 cM-D14Mit5-telomere Method of mapping: Intersubspecific backcross mice were used paralogous, that is, have arisen as a result of regional chromosome for genetic mapping: (C57BL/6 � MSM)F 1 females � MSM males. duplication . Moreover, these results expand the notion that Rab Haplotype analysis is summarized in Fig. 1. genes are widely dispersed throughout the mouse genome . Molecular reagents: The primer sequences used for typing the The chromosomal localization of genes in the mouse can en- backcross mice are 5'-GAGAACTCAGTCTTGTATCCG-3' and able prediction of the location of human
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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