Mouse homeobox-containing gene, Otx2, maps to mouse Chromosome 14

Mouse homeobox-containing gene, Otx2, maps to mouse Chromosome 14 292 Mammalian Genome 8, Brief Data Reports Fig. 1. Genetic mapping of Rab20 on Genetics (IMEG), Kumamoto University School of Medicine, mouse Chr 8. Segregation of D8MiH, 2-2-1 Honjo, Kumamoto 860, Japan Rab20, and D8Mit4 on mouse Chr 8 in 93 [C57BL/6J-bg x (C57BL6J-bg x Received: 16 August 1996 / Accepted: 2 December 1996 CAST/EiJ)FI] intersubspecific backcross DSMitl mice. Closed boxes represent the homo- Ra 20 m mDm Species: Mouse zygous B6 pattern, and open boxes the F1 DSMit4 m mmG Locus name: orthodenticle-related homeobox-2 pattern. Numbers of mice of each haplo- Locus symbol: Otx2 #of mice 39 51 1 1 1 type are indicated. Map position: centromere-D14Mit3-8.4 cM-Otx2, D14Mit101- 4.5 cM-D14Mit5-telomere Method of mapping: Intersubspecific backcross mice were used paralogous, that is, have arisen as a result of regional chromosome for genetic mapping: (C57BL/6 � MSM)F 1 females � MSM males. duplication [9]. Moreover, these results expand the notion that Rab Haplotype analysis is summarized in Fig. 1. genes are widely dispersed throughout the mouse genome [1]. Molecular reagents: The primer sequences used for typing the The chromosomal localization of genes in the mouse can en- backcross mice are 5'-GAGAACTCAGTCTTGTATCCG-3' and able prediction of the location of human Mammalian Genome Springer Journals

Mouse homeobox-containing gene, Otx2, maps to mouse Chromosome 14

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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