Mamm Genome (2012) 23:479–489 DOI 10.1007/s00335-012-9429-8 IN TROD UCTIO N The mouse: pushing the boundaries • • Maja Bucan Janan T. Eppig Steve Brown Published online: 12 September 2012 Springer Science+Business Media, LLC 2012 This year we celebrate 10 years since the publication of the phenotype-based screens was reduced to sifting through a draft genome sequence of the C57BL/6J mouse inbred list of annotated genes in a critical interval. However, strain. Initial and ongoing comparative sequence analysis having a reference sequence for only one inbred strain is continues to highlight the mouse as a leading model for very limiting. For decades, the biomedical community has studying human biology and disease. The availability of the explored the rich biology and phenotypic diversity of many reference sequence transformed the efforts of individual inbred strains and their combined genomes. A recent report laboratories to understand the function of a speciﬁc on the whole genome sequence of 17 inbred strains gene(s) by studying mouse mutants. Moreover, the mouse explored sequence variation for both single nucleotide and genetic community recognized the opportunity to build on structural variants, signiﬁcantly illuminating genetic vari- and take advantage of the mouse genome sequence for the ation and associated
Mammalian Genome – Springer Journals
Published: Sep 12, 2012
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