Mammalian Genome 10, 943 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Rebecca A. Liddell,** Mari C. Hirano, Beverly A. Mock* Laboratory of Genetics, DBS, National Cancer Institute, National Institutes of Health, Building 37, Room 2B-08, 37 Convent Dr., MSC 4255, Bethesda, Maryland 20892-4255 USA Submitted: 9 December 1998 Introduction This year’s report incorporates 78 new genetic markers into the some. New loci were incorporated onto the backbone map by consensus linkage map. Of these markers, ten have a known, determining the proportional interval lengths between the back- mapped human homolog. The murine gene, followed by the hu- bone interval and that of the individual cross used to position the man homolog and the human chromosomal location in parenthesis new locus. Due to the high marker density on the consensus map, are as follows: Cpt2 4 CPT2 (1p32); Cyp2j5 and Cyp2j6 4 confidence in gene order is low. The gene order of markers CYP2J2 (1p31.3-p31.2); Guca1b 4 GUCA2B (1p34-p33); Htr6 designated with a blackened circle is relatively certain. This year, 4 HTR6 (1p36-1p35); Hub 4 ELAVL2 (9p21); Hud 4 at the 12th IMGC chromosome committee meeting, it was agreed ELAVL4 (1p34); Matn1 4 MATN1 (1p35); Mmp16 4 MMP16 to release the full Chr 4 map only on the MGD website (www. (8q21.3-q22.1); Tgfbr1 4 TGFBR1 (9q33-q34). In the case of the informatics.jax.org). This publication is a brief summary of addi- Cyp genes, two genes have been identified in mouse while only a tions and changes made to the 1998 report. single gene has been identified in humans. Mouse Chromosome (Chr) 4 shares significant stretches of linkage homology with hu- Physical map data man Chr 1, 6, 8, 9 and 21 (34245; 23572). The entire distal half of The Chr 4 website also incorporates two columns listing the names mouse Chr 4 is homologous with human Chr 1p. There have been of YAC/P1/BAC/Cosmid clones that have been isolated from cer- four changes in nomenclature of genetic loci on Chr 4. Gene names tain regions of the chromosome. and/or symbols that have been changed by the Nomenclature Com- mittee include: Cerr1 changed to Cer1; Dana changed to New loci mapping to 10 cM intervals of the chromosome D4H1s1733E; Zie changed to Gklf; and Etl2 changed to Il11ra2. The following provides a brief listing of markers mapping to spe- cific intervals of the chromosome: 0–10 cM (Mos-Cga): Aop2-rs, Construction of the map Bwq1, D4Erdt360e, D4Erdt389e, D4Erdt510e, D4Erdt582e, D4Erdt800e, Mmp16, Tcm; 11–20 cM (Cga-Aco1): D4Erdt199e, As in all previous reports, the consensus map was constructed D4Erdt279e, D4Erdt628e, D4Erdt659e, Plt, Tgfbr1; 21–30 cM initially from multilocus backcross data which involved a large (Aco1-Lv): D4Erdt335e, D4Erdt346e; 31–40 cM (Lv-Adfp): none; number of meiotic events. Crosses typed for the largest number of 41–50 cM (Adfp-Tie1): Cer1, Cyp2j5, Cyp2j6, D4Erdt321e, expressed genes (14384; 29505; 29138; 10819; 20039) were es- D4Erdt513e, D4Erdt618e, D4Erdt681e, D4Erdt786e, D4Ucl2, sential in constructing the primary backbone map of the chromo- D4Ucl3, Hub, Hud, Ifna11, Papg1; 51–60 cM (Tiel-Synd3): Aaiq1, Aaiq2, Cpt2, D4Erdt111e, D4Erdt184e, D4Erdt314e, D4Erdt361e, D4Erdt421e, D4Erdt561e, D4Erdt617e, D4Erdt639e, * Committee Chair D4Erdt669e, D4Erdt765e, D4Erdt767e, D4Erdt796e, D4Erdt804e, ** Co-chair D4Jcs23, D4Xrf534, Guca1b, Lmb1; 61–70 cM (Synd3-Gt10): D4Erdt442e, D4Erdt478e, D4Erdt632e, D4Erdt810e, D4Ggc3e, Correspondence to: B.A. Mock (email:firstname.lastname@example.org) D4Jcs21, D4Xrf562, Htr6, Matn1, Ptpro, Rhl1, Swe; 71–80 cM Members of the Mouse Chromosome 4 Committee present at the 12th (Gt10-Gnb1): Cd137, D4Erdt429e, D4Erdt432e, D4Erdt571e, IMGC in Garmisch/Partenkirchen, Bavaria, Germany; Alexander Bach- D4Erdt792e, Ftl1-rs5, Mpsq1; 81 cM-Tel (Gnb1-Tel): D4Xrf472, manov (Sac), Michael Coleman (Wld), Laura Conforti (Wld), Michel Her- ranz (Tlsr loci), Ian Jackson (Tyrp 1), Rebecca Liddell (Pctr 2, 3), Paul D4Xrf497, Hes2; Syntenic: Alcw2, Casr-rs3, Loh3, Nidd1, Tesk1. Lyons (Idd), Beverly Mock (Pctr 1–3), Javier Santos (Tlsr loci) and Jon Stoye (Fv1). These individuals are interested in Chr 4 loci indicated in Acknowledgments. The assistance of Lois Maltais with nomenclature is- parenthesis following their name. sues was greatly appreciated.
Mammalian Genome – Springer Journals
Published: Oct 1, 1999
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