Mammalian Genome 10, 956 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 1 1 1 2 Konrad Huppi,* David Siwarski, Jennifer Kim, Verity Letts** Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Building 37, Rm. 2B-21, Bethesda, MD 20892-4255, USA The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA Submitted: 10 December 1998 Introduction This report summarizes the information available on mouse Chro- from one of the 56 multilocus crosses (Table 2) and in direct mosome 15 (Chr 15) to date. A consensus linkage map (Table comparison to the position of the closest anchor locus. Any of the 1/Map) has been constructed and is reassessed on a yearly basis to loci positioned by the above critieria have been assigned a confi- serve as a guide for genetic and molecular interpretation as well as dence level of 1 (Table 1/Map, column 4). 3) Other loci that were comparison to the human homologues. not mapped with regard to anchor loci, or by less accurate means, i.e., in situ hybridization or QTL, were given a map position, but assigned a confidence level of 2 or 3 (see legend to Table 1/Map). Construction of the chromosome 15 map The reader is reminded that the order of markers is most accurately determined from within the same cross and, for the most part, is Presently, 731 loci have been mapped to Chr 15, including ap- derived from female meiotic events in M. spretus interspecific proximately 26 mutations with visible phenotypes. Since the pre- backcrosses. Therefore, the gene order and distance between mark- vious Chr 15 reports (23573, 23575, 25575, 34246), a total of 44 ers presented in Table 1/Map may differ between species, sex or as new loci have been mapped. This year, high resolution mapping of a consequence of a smaller sample size. Readers are encouraged to the dominant megacolon (dom) locus has yielded an exciting new refer back to the original data as often as possible to obtain the candidate gene, Sox10 for Hirschsprung disease (45117). In addi- most direct correlation between loci. tion, several new Quantitative Trait loci (QTL) have been pub- lished that map to Chr 15 including sex-specific modifiers of tail development (Brm2, 45873), dietary obesity (Dob9, 35460) and YAC contigs and physical mapping data alcohol acceptance (Aaq1, 43654). Table 1/Map includes a com- pilation of all loci identified on Chr 15 including new markers, In the previous reports, the reader will find some discussions of symbols, a description of the locus, the relative map position, the physical mapping and reference to YAC contigs for Chr 15. Since method by which the map position was determined, the human newer YACs are now available, we have included these contigs in symbol/location, markers that have been assigned to YAC contigs Table 1/Map and in Table 3. The reader can look forward to further and finally references. Map positions (Table 1/Map, column 2) development in this exciting area in the next year as the physical were established with the following criteria: 1) The traditional map is completed. anchor loci, i.e., genetic markers analyzed in multiple backcrosses that are in excess of 1000 meioses (S.E.<+0.1cM) are the follow- Quantitative trait loci ing: (Mlvi2, Ghr, Prlr, Il7r, Lifr, Slc1a3), (D15Mit13, Rnr15), D15Mit11, Hba-ps3, D15Mit17, (Myc, Mlvi4, Pvt1), D15Mit3, The use of quantitative trait loci (QTL) analysis has been shown to Ly6, (D15Mit29,D15Mit33), D15Mit31, D15Mit30, (D15Mit14, facilitate multipoint mapping of genetic loci that affect a quanti- D15Kz2), (Gdc1, Wnt1, Wnt12,Ela1, Tcfcp2, Emb, Pmv42, tative phenotype in a continuous manner. The following QTL loci Pmv36), and D15Mit16. 2) Additional loci have been mapped have been mapped to CHR15: Dob3/Dob4 (20700, 35460), Mob4 (24238), Bhr2 (29231), Daq 12/Daq13 (42413), Faq8 (42413), * Committee Chair Lore (38534]). This year, new QTLs mapped are sex-specific ** Co-Chair modifiers of tail development (Brm2-45873), dietary obesity Correspondence to: K. Huppi (Dob9-35460) and alcohol acceptance (Aaq1-43654).
Mammalian Genome – Springer Journals
Published: Oct 1, 1999
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