Mammalian Genome 10, 955 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Rosemary W. Elliott* Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm Street at Carlton Street, Buffalo New York 14263, USA Submitted: 13 March 1999 Introduction The 1999 version of the consensus map of Chr 14 is shown in the moved from the chromosome and are now listed as unmapped. The accompanying figure. It was based on the previous year’s map, mapping data previously used for Lhr had been erroneously asso- which divided the 69 map units into bins and assigned positions of ciated with that locus, and the AXBXA RI data used for mapping genes and other markers using the Copeland-Jenkins, EUCIB, were no longer convincing, with LOD scores for linkage to any Jackson Laboratory, and MIT genetic mapping panels. Data from marker on Chr 14 being less than 1. Mutations are indicated by a the Seldin, Kozak and other mapping panels were integrated into T in column 6, and several genes on the chromosome are repre- this framework. New loci have been added, some syntenic markers sented by targeted mutations. have been localized and new orthologies to human loci listed. The Of the genes mapped on Chr 14, 81 have known counterparts positions of all genes were checked against flanking markers and in the human map. These are mainly found on five human chro- a number of loci were moved to eliminate ambiguities due to mosomes, 3, 8, 10, 13 and 14. Single loci are found on human integration of markers not typed in the same cross. chromosomes 21 (Vdac2) and X/Y (Il3ra). The ten loci that are There are a total of 856 entries, of which 108 are associated orthologous with human Chr 3p are all at the proximal end of Chr with the Tcra gene complex. The entries include 22 translocations, 14. The fifteen loci orthologous to human Chr 10q are found over 19 deletions, 3 inversions and 2 duplications. There are 73 new the same region of mouse Chr 14, from position 2.5 to position entries, of which 69 are localized on the chromosome and 4 are 15.5. The 23 loci syntenic with human Chr 14q span the region syntenic. These loci include 29 new named genes or related se- from position 12 to 22, including Tcra. They are intermingled with quences, 25 of which are localized on the map. The other new loci orthologous to Chrs 8 and 10. It is not clear whether this entries are mainly ESTs. intermingling is due to inversions, or to imprecise mapping. There The loci include 125 named genes mapped on Chr 14, with a are 14 loci orthologous to human Chr 8p. Except for one locus at further 18 that are syntenic, for a total of 143 named genes. There position 3, these all lie in the region just distal to Tcra. Most of the are 28 sequences related to genes, of which 23 are localized on the 19 loci syntenic with Chr 13q are at the distal end of mouse Chr 14, chromosome, and 37 ESTs, all of which are localized. If one from about position 40 to the terminus. However, three loci that assumes that there are 80,000 genes, this represents perhaps 5% of are close to the centromere on human Chr 13 are at position 20, the genes expected to be on Chr 14. close to Tcra. Twenty-six loci previously listed as syntenic have been placed on the map, and three loci, previously given positions were moved Acknowledgments. The author would like to acknowledge the work of the to the syntenic group. Two loci, Lhr (leutinizing hormone recep- previous chair, Dr. Joseph Nadeau, who developed the framework map for tor) and amd (autoimmune myocardial disease) have been re- Chr 14, on which the current map was based. The assistance of Dirck Bradt and David Shaw from mgi-help was much appreciated. Support was pro- * Committee Chair vided by the New York State Department of Health.
Mammalian Genome – Springer Journals
Published: Oct 1, 1999
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