Mouse Chromosome 12
* Roy Riblet
Department of Biochemistry and Kaplan Cancer Center, NYU School of Medicine, 550 First Avenue, New York NY 10016, USA
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121-1122 USA
Submitted: 1 December 1998
Comprehensive primary genetic data for the mouse are provided
by the Mouse Genome Database (MGD) and several more spe-
cialized databases accessible via the World-Wide Web. This report
is useful as an entry point to allow users to note the genes and
markers likely to fall in a physical or genetic sub-region of Chro-
mosome 12, preparatory to a search of MGD and other primary
resources to retrieve complete data.
The genetic organization of Chromosome 12 (Table 1) is
largely unchanged: newly mapped markers (noted with asterisks in
Table 1) have been interpolated into the 62-bin map of Chromosome
12 developed previously (26922) without affecting either the length
of the map or the placements of previously well-mapped markers.
Reliability of marker placement in the genetic map has been
indicated on a scale from 1 (most reliable) to 3 (least reliable).
These indications should be viewed cautiously. Marker orders de-
termined from patterns of co-segregation within a single cross can
be highly reliable, but marker orders determined by interpolation
of data from different crosses are often unreliable, even when the
individual crosses each yielded reliable orders. Data obtained by
following the inheritance of chromosomal rearrangements and
translocations cytogenetically in a cross segregating for conven-
tional markers present an extreme form of this difficulty, as cross-
ing over is strongly perturbed in the vicinity of many rearrange-
ments (e.g., 3979). As a result, Robertsonian translocations are
assigned to the centromere of the cytogenetic map and bin 0 of the
genetic map of Chromosome 12, but with a reliability score of 3,
and all other chromosomal rearrangements are classified as syn-
tenic, regardless of the amount or quality of available genetic data
concerning the rearrangement.
* Committee Chair
Correspondence to: P.D’Eustachio
Mammalian Genome 10, 953 (1999).
© Springer-Verlag New York Inc. 1999