Mammalian Genome 10, 953 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 1 2 Peter D’Eustachio, * Roy Riblet ** Department of Biochemistry and Kaplan Cancer Center, NYU School of Medicine, 550 First Avenue, New York NY 10016, USA Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121-1122 USA Submitted: 1 December 1998 Introduction Comprehensive primary genetic data for the mouse are provided Reliability of marker placement in the genetic map has been by the Mouse Genome Database (MGD) and several more spe- indicated on a scale from 1 (most reliable) to 3 (least reliable). cialized databases accessible via the World-Wide Web. This report These indications should be viewed cautiously. Marker orders de- is useful as an entry point to allow users to note the genes and termined from patterns of co-segregation within a single cross can markers likely to fall in a physical or genetic sub-region of Chro- be highly reliable, but marker orders determined by interpolation mosome 12, preparatory to a search of MGD and other primary of data from different crosses are often unreliable, even when the resources to retrieve complete data. individual crosses each yielded reliable orders. Data obtained by The genetic organization of Chromosome 12 (Table 1) is following the inheritance of chromosomal rearrangements and largely unchanged: newly mapped markers (noted with asterisks in translocations cytogenetically in a cross segregating for conven- Table 1) have been interpolated into the 62-bin map of Chromosome tional markers present an extreme form of this difficulty, as cross- 12 developed previously (26922) without affecting either the length ing over is strongly perturbed in the vicinity of many rearrange- of the map or the placements of previously well-mapped markers. ments (e.g., 3979). As a result, Robertsonian translocations are assigned to the centromere of the cytogenetic map and bin 0 of the genetic map of Chromosome 12, but with a reliability score of 3, * Committee Chair and all other chromosomal rearrangements are classified as syn- ** Co-Chair tenic, regardless of the amount or quality of available genetic data Correspondence to: P.D’Eustachio concerning the rearrangement.
Mammalian Genome – Springer Journals
Published: Oct 1, 1999
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