Ann Surg Oncol (2018) 25:1912–1920 https://doi.org/10.1245/s10434-018-6422-9 OR IG INA L A R TIC L E – BREA S T O NC OLOG Y Most Breast Cancer Patients with T1-2 Tumors and One to Three Positive Lymph Nodes Do Not Need Postmastectomy Radiotherapy 1 1 2 1 Shirin Muhsen, MD , Tracy-Ann Moo, MD , Sujata Patil, PhD , Michelle Stempel, MPH , Simon Powell, MD, 3 1 1 PhD , Monica Morrow, MD , and Mahmoud El-Tamer, MD 1 2 Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY ABSTRACT tumors (p = 0.0013), higher histologic grade (p = 0.029), Background/Objective. Guidelines concur that postmas- more positive LNs (p \ 0.0001), lymphovascular invasion tectomy radiation therapy (PMRT) in T1-2 tumors with one (LVI) (p \ 0.0001), extracapsular nodal extension to three positive (?) lymph nodes (LNs) decreases (p \ 0.0001), and macroscopic LN metastases locoregional recurrence (LRR) but advise limiting PMRT (p \ 0.0001). There was no difference in LRR, RFS, or OS to patients at highest risk to balance
Annals of Surgical Oncology – Springer Journals
Published: Mar 21, 2018
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