Morphogenesis of human fetal thymus during weeks 22–27 of development

Morphogenesis of human fetal thymus during weeks 22–27 of development Distinctive features of human fetal thymus morphogenesis in early ontogeny in the case ofuncomplicated pregnancy have been characterized. A steady increase of thymus dimensions and weightoccurred concomitantly to differentiation of morphofunctional zones within the organ. Cell differentiationin the subcapsular and inner cortical zones of the thymus lobes was manifested as changes in parameters ofexpression of T-lymphocyte antigens CD1, CD2, and CD3 and ultrastructural features of reticuloepithelialcells (REC) type I and II forming a microenvironment for lymphocytes. RECs of the medullar zone formeda glomerular syncytium with desmosomal interepithelial contacts by week 22 of fetal development. Smalllymphocytes predominated among thymocytes (66%). Hassall’s corpuscles, the structural correlates of mor-phological and functional maturity, predominated in the fetal thymuses during developmental weeks 25–27. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Morphogenesis of human fetal thymus during weeks 22–27 of development

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360415040049
Publisher site
See Article on Publisher Site

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