Purpose of Review Autoimmune inner ear disease (AIED) is a rare disease of unknown etiology characterized by a sudden decline in hearing. Although AIED is initially responsive to corticosteroid therapy, this response is lost over time. We recently demonstrated in a small cohort of corticosteroid-resistant AIED patients that IL-1 was overexpressed in the plasma and that IL-1 antagonism led to hearing improvement and reduction in circulating IL-1. Autoinflammatory diseases, such as Muckle-Wells syndrome (MWS), are diseases of the innate immune system whose phenotype includes sensorineural hearing loss. Monocytes are the primary cells orches- trating the inflammatory response in this family of diseases, due to a gain-of-function mutation that causes excessive IL-1 release. Recent Findings We have observed that monocytes from AIED patients release excessive IL-1 and behave similarly to mono- cytes from Muckle-Wells patients, despite the lack of pathogenic mutations and other characteristic phenotypic manifestations. Unlike MWS, we have observed substantially greater hearing improvement with IL-1 antagonism than hearing improvement reported in MWS. Summary The role of monocytes, macrophages, and microglia and the cytokines they secrete are of critical importance in both understanding disease mechanism and identification of novel therapeutic targets to treat chronic inflammatory diseases of the cochlea
Current Otorhinolaryngology Reports – Springer Journals
Published: Apr 10, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera