Monitoring early response to chemoradiotherapy with 18F-FMISO dynamic PET in head and neck cancer

Monitoring early response to chemoradiotherapy with 18F-FMISO dynamic PET in head and neck cancer Eur J Nucl Med Mol Imaging (2017) 44:1682–1691 DOI 10.1007/s00259-017-3720-6 ORIGINAL ARTICLE Monitoring early response to chemoradiotherapy with F-FMISO dynamic PET in head and neck cancer 1 2 3 3 Milan Grkovski & Nancy Y. Lee & Heiko Schöder & Sean D. Carlin & 1 2 2 Bradley J. Beattie & Nadeem Riaz & Jonathan E. Leeman & 1 1 Joseph A. O’Donoghue & John L. Humm Received: 21 February 2017 /Accepted: 3 May 2017 /Published online: 24 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract Ratios (TMR) were derived by visual inspection by an expe- Purpose There is growing recognition that biologic features rienced nuclear medicine physician, with TMR > 1.2 defining of the tumor microenvironment affect the response to cancer hypoxia. therapies and the outcome of cancer patients. In head and neck Results One hundred and thirty-five lesions in total were an- cancer (HNC) one such feature is hypoxia. We investigated alyzed. TBR, k and DV decreased on early response scans, the utility of F-fluoromisonidazole (FMISO) dynamic posi- while no significant change was observed for K .The k -TBR 1 3 tron emission tomography (dPET) for monitoring the early correlation decreased substantially from baseline scans microenvironmental response to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Nuclear Medicine and Molecular Imaging Springer Journals

Monitoring early response to chemoradiotherapy with 18F-FMISO dynamic PET in head and neck cancer

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
ISSN
1619-7070
eISSN
1619-7089
D.O.I.
10.1007/s00259-017-3720-6
Publisher site
See Article on Publisher Site

Abstract

Eur J Nucl Med Mol Imaging (2017) 44:1682–1691 DOI 10.1007/s00259-017-3720-6 ORIGINAL ARTICLE Monitoring early response to chemoradiotherapy with F-FMISO dynamic PET in head and neck cancer 1 2 3 3 Milan Grkovski & Nancy Y. Lee & Heiko Schöder & Sean D. Carlin & 1 2 2 Bradley J. Beattie & Nadeem Riaz & Jonathan E. Leeman & 1 1 Joseph A. O’Donoghue & John L. Humm Received: 21 February 2017 /Accepted: 3 May 2017 /Published online: 24 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract Ratios (TMR) were derived by visual inspection by an expe- Purpose There is growing recognition that biologic features rienced nuclear medicine physician, with TMR > 1.2 defining of the tumor microenvironment affect the response to cancer hypoxia. therapies and the outcome of cancer patients. In head and neck Results One hundred and thirty-five lesions in total were an- cancer (HNC) one such feature is hypoxia. We investigated alyzed. TBR, k and DV decreased on early response scans, the utility of F-fluoromisonidazole (FMISO) dynamic posi- while no significant change was observed for K .The k -TBR 1 3 tron emission tomography (dPET) for monitoring the early correlation decreased substantially from baseline scans microenvironmental response to

Journal

European Journal of Nuclear Medicine and Molecular ImagingSpringer Journals

Published: May 24, 2017

References

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