Monitoring early response to chemoradiotherapy with 18F-FMISO dynamic PET in head and neck cancer

Monitoring early response to chemoradiotherapy with 18F-FMISO dynamic PET in head and neck cancer Eur J Nucl Med Mol Imaging (2017) 44:1682–1691 DOI 10.1007/s00259-017-3720-6 ORIGINAL ARTICLE Monitoring early response to chemoradiotherapy with F-FMISO dynamic PET in head and neck cancer 1 2 3 3 Milan Grkovski & Nancy Y. Lee & Heiko Schöder & Sean D. Carlin & 1 2 2 Bradley J. Beattie & Nadeem Riaz & Jonathan E. Leeman & 1 1 Joseph A. O’Donoghue & John L. Humm Received: 21 February 2017 /Accepted: 3 May 2017 /Published online: 24 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract Ratios (TMR) were derived by visual inspection by an expe- Purpose There is growing recognition that biologic features rienced nuclear medicine physician, with TMR > 1.2 defining of the tumor microenvironment affect the response to cancer hypoxia. therapies and the outcome of cancer patients. In head and neck Results One hundred and thirty-five lesions in total were an- cancer (HNC) one such feature is hypoxia. We investigated alyzed. TBR, k and DV decreased on early response scans, the utility of F-fluoromisonidazole (FMISO) dynamic posi- while no significant change was observed for K .The k -TBR 1 3 tron emission tomography (dPET) for monitoring the early correlation decreased substantially from baseline scans microenvironmental response to European Journal of Nuclear Medicine and Molecular Imaging Springer Journals

Monitoring early response to chemoradiotherapy with 18F-FMISO dynamic PET in head and neck cancer

Loading next page...
Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial