Eur J Nucl Med Mol Imaging (2017) 44:1682–1691 DOI 10.1007/s00259-017-3720-6 ORIGINAL ARTICLE Monitoring early response to chemoradiotherapy with F-FMISO dynamic PET in head and neck cancer 1 2 3 3 Milan Grkovski & Nancy Y. Lee & Heiko Schöder & Sean D. Carlin & 1 2 2 Bradley J. Beattie & Nadeem Riaz & Jonathan E. Leeman & 1 1 Joseph A. O’Donoghue & John L. Humm Received: 21 February 2017 /Accepted: 3 May 2017 /Published online: 24 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract Ratios (TMR) were derived by visual inspection by an expe- Purpose There is growing recognition that biologic features rienced nuclear medicine physician, with TMR > 1.2 defining of the tumor microenvironment affect the response to cancer hypoxia. therapies and the outcome of cancer patients. In head and neck Results One hundred and thirty-five lesions in total were an- cancer (HNC) one such feature is hypoxia. We investigated alyzed. TBR, k and DV decreased on early response scans, the utility of F-fluoromisonidazole (FMISO) dynamic posi- while no significant change was observed for K .The k -TBR 1 3 tron emission tomography (dPET) for monitoring the early correlation decreased substantially from baseline scans microenvironmental response to
European Journal of Nuclear Medicine and Molecular Imaging – Springer Journals
Published: May 24, 2017
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