Molecularly imprinted polymer for L-tyrosine recognition and controlled release

Molecularly imprinted polymer for L-tyrosine recognition and controlled release Molecularly imprinted membranes (MIMs) with combined properties of molecular recognition and controlled release were prepared and characterized. MIMs were synthesized by the co-polymerization of chitosan (CS) and gelatine (GEL) in aqueous phase, using L-tyrosine as an imprinting molecule and polyethylene glycol (PEG) as a porogen. Binding experiments were carried out to evaluate the properties of MIMs and nonmolecularly imprinted membranes (NIMs). The results demonstrated that the MIMs with diameters of about 500 nm had high adsorption capacity and selectivity to L-tyrosine (L-tyr). Moreover, release profiles and release rate of L-tyrosine from the L-tyrosine-loaded MIMs indicated that the MIMs also had potential applications in drug controlled release. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Applied Chemistry Springer Journals

Molecularly imprinted polymer for L-tyrosine recognition and controlled release

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Ltd.
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
1070-4272
eISSN
1608-3296
D.O.I.
10.1134/S1070427215010231
Publisher site
See Article on Publisher Site

Abstract

Molecularly imprinted membranes (MIMs) with combined properties of molecular recognition and controlled release were prepared and characterized. MIMs were synthesized by the co-polymerization of chitosan (CS) and gelatine (GEL) in aqueous phase, using L-tyrosine as an imprinting molecule and polyethylene glycol (PEG) as a porogen. Binding experiments were carried out to evaluate the properties of MIMs and nonmolecularly imprinted membranes (NIMs). The results demonstrated that the MIMs with diameters of about 500 nm had high adsorption capacity and selectivity to L-tyrosine (L-tyr). Moreover, release profiles and release rate of L-tyrosine from the L-tyrosine-loaded MIMs indicated that the MIMs also had potential applications in drug controlled release.

Journal

Russian Journal of Applied ChemistrySpringer Journals

Published: Apr 16, 2015

References

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