Trimolecular salt Michael adducts 2a–c were synthesized in excellent yields up to 92 % via one-pot multicomponent reactions in an aqueous medium. The chemical structures of compounds 2a–c were characterized by X-ray single-crystal diffraction techniques. Calculations of the density functional theory for the synthesized compound were performed. The stability of the products was deduced by TGA analysis. Compounds 2a–c were screened in vitro for different bio-assays such as thymidine phosphorylase inhibition assay, urease inhibition assay, β-glucuronidase inhibition assays and cytotoxicity against PC-3 and HeLa cell lines.
Research on Chemical Intermediates – Springer Journals
Published: Sep 11, 2015
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