J. Membrane Biol. 175, 1–8 (2000) The Journal of Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review A.M. Pajor Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555-0641, USA Received: 20 December 1999 Introduction ily that includes the Na /sulfate cotransporters: NaSi-1, from kidney and intestine and SUT-1, from endothelial The active transport of Krebs cycle intermediates, such cells (Table 1). The members of the NaDC/NaSi family as succinate, a-ketoglutarate and citrate, is mediated by are not related to any of the di- and tricarboxylate trans- sodium-coupled transporters found on the plasma mem- porters from bacteria or from mammalian mitochondria. branes of many epithelial cells. The preferred substrates + The first Na /dicarboxylate cotransporter to be of these transporters are dicarboxylates. Tricarboxylate cloned was isolated from a rabbit kidney cortex cDNA substrates, such as citrate, are carried in protonated form. library using the technique of functional expression in At least two classes of Na /dicarboxylate cotransporters Xenopus oocytes . The rbNaDC-1 corresponds to have been identified, distinguished by differences in their the low affinity Na /dicarboxylate cotransporter of the relative affinity for succinate. The low affinity transport- apical membrane of the renal proximal
The Journal of Membrane Biology – Springer Journals
Published: May 1, 2000
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