Russian Journal of Applied Chemistry, 2012, Vol. 85, No. 11, pp. 1732−1739.
Pleiades Publishing, Ltd., 2012.
Original Russian Text © N.P. Yevlampieva, O.V. Nazarova, A.P. Khurchak, E.I. Ryumtsev, E.F. Panarin, 2012, published in Zhurnal Prikladnoi Khimii,
2012, Vol. 85, No. 11, pp. 1825−1832.
AND POLYMERIC MATERIALS
in Aqueous Solvents of Various Compositions
N. P. Yevlampieva
, O. V. Nazarova
, A. P. Khurchak
, E. I. Ryumtsev
, and E. F. Panarin
Fock Research Institute of Physics, St. Petersburg State University, St. Petersburg, Russia
Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia
Received September 9, 2012
Abstract—Six samples of poly(2-deoxy-2-methacryloylamino-D-glucose) were prepared by free-radical po-
lymerization of the monomer. The molecular properties of the homologous series obtained were studied in three
solvents, 0.2 M NaCl, 0.1 M Na
, and salt-free water, by viscometry and static and dynamic light scattering.
The Mark-Kuhn–Houwink relationships were obtained. The poly(vinyl saccharide) studied, despite the presence
of bulky pendant substituents, is a typical ﬂ exible-chain polymer with the Kuhn segment length of 20 ± 3 Å. In
aqueous salt systems, poly(2-deoxy-2-methacryloylamino-D-glucose), which is not a polyelectrolyte, neverthe-
less demonstrates the dependence of the hydrodynamic size of the molecules on the solvent composition. The
ions make the polymer molecules more compact, whereas Сl
ions present in aqueous solution lead to its
expanding. Salt additions affect the thermodynamic quality of the polymer–solvent system.
The signiﬁ cance of water-soluble synthetic polymers
for modern biotechnologies is difﬁ cult to overestimate.
They execute diverse functions as components of poly-
mer–inorganic composites of scaffold type [1, 2]. They
can also be used in targeting delivery systems of gene
material and drugs into cells of living organisms [1, 3], for
the development of new vaccines and pharmaceuticals of
dosed action , and in medical coatings . Combina-
tion of nonbiodegradable backbone with biocompatible
pendant substituents imparts to the polymers the set of
properties required for many modern biotechnologies.
Among such polymers are poly(vinyl saccharides) [2–5].
One of their representatives is poly(2-deoxy-2-methac-
Commercial use of modern biotechnologies requires
the development of water-soluble polymers that should
meet a number of requirements along with having suit-
able functional properties: They should be nontoxic, and
their synthesis and isolation should not require much
energy and expensive chemicals and catalysts. In this
respect, PMAG can be considered as an economically
advantageous multifunctional poly(vinyl saccharide) with
high potential for industrial application. Examination
of synthesis features and detailed analysis of molecular
properties of PMAG are topical for such rapidly devel-
oping ﬁ elds as tissue engineering [1, 5], immunotherapy
, and other high-tech biotechnologies .
Despite the fact that a procedure for preparing
PMAG was suggested as early as late 1980s , the
molecular properties of this polymer have not been
studied exhaustively. In particular, the scaling relationship
between the intrinsic viscosity and molecular weight
of PMAG, obtained in  and practically used now
[2, 8], was evaluated from data on only three samples
with the molecular weights of about 10
hydrodynamic properties of a wide homologous series of