Molecular Properties of Hepatic Uptake Systems for Bile Acids and Organic Anions

Molecular Properties of Hepatic Uptake Systems for Bile Acids and Organic Anions J. Membrane Biol. 160, 1–8 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review B. Hagenbuch Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8091 Zurich, Switzerland Received: 13 March 1997/Revised: 3 June 1997 Introduction riers at the canalicular membrane into bile [95]. In ad- dition, for proper metabolism, transport proteins for metabolic substrates such as, for example, glucose [119], Transport proteins are a necessity for the proper function amino acids [92], Krebs cycle intermediates [140] and of the liver and are intrinsically involved in all of the coenzymes [61] are also found in the hepatocyte plasma major functions of hepatocytes such as, for example, bile membrane. formation, detoxification and metabolism. Bile provides a main excretory pathway for various organic com- pounds that cannot be eliminated by the kidneys. There- Functional Characterization of Transport Systems fore, to generate ongoing bile flow hepatocytes must in Hepatocytes continuously transport bile acids from portal blood into bile. This transcellular transport process is driven by Initially, elimination of compounds by the liver was stud- several active transport proteins at the basolateral and the ied using the isolated perfused rat liver. With this ex- canalicular membrane The Journal of Membrane Biology Springer Journals

Molecular Properties of Hepatic Uptake Systems for Bile Acids and Organic Anions

Loading next page...
Copyright © Inc. by 1997 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial