Molecular Properties of Hepatic Uptake Systems for Bile Acids and Organic Anions

Molecular Properties of Hepatic Uptake Systems for Bile Acids and Organic Anions J. Membrane Biol. 160, 1–8 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review B. Hagenbuch Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8091 Zurich, Switzerland Received: 13 March 1997/Revised: 3 June 1997 Introduction riers at the canalicular membrane into bile [95]. In ad- dition, for proper metabolism, transport proteins for metabolic substrates such as, for example, glucose [119], Transport proteins are a necessity for the proper function amino acids [92], Krebs cycle intermediates [140] and of the liver and are intrinsically involved in all of the coenzymes [61] are also found in the hepatocyte plasma major functions of hepatocytes such as, for example, bile membrane. formation, detoxification and metabolism. Bile provides a main excretory pathway for various organic com- pounds that cannot be eliminated by the kidneys. There- Functional Characterization of Transport Systems fore, to generate ongoing bile flow hepatocytes must in Hepatocytes continuously transport bile acids from portal blood into bile. This transcellular transport process is driven by Initially, elimination of compounds by the liver was stud- several active transport proteins at the basolateral and the ied using the isolated perfused rat liver. With this ex- canalicular membrane http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Molecular Properties of Hepatic Uptake Systems for Bile Acids and Organic Anions

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Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 1997 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900290
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 160, 1–8 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review B. Hagenbuch Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8091 Zurich, Switzerland Received: 13 March 1997/Revised: 3 June 1997 Introduction riers at the canalicular membrane into bile [95]. In ad- dition, for proper metabolism, transport proteins for metabolic substrates such as, for example, glucose [119], Transport proteins are a necessity for the proper function amino acids [92], Krebs cycle intermediates [140] and of the liver and are intrinsically involved in all of the coenzymes [61] are also found in the hepatocyte plasma major functions of hepatocytes such as, for example, bile membrane. formation, detoxification and metabolism. Bile provides a main excretory pathway for various organic com- pounds that cannot be eliminated by the kidneys. There- Functional Characterization of Transport Systems fore, to generate ongoing bile flow hepatocytes must in Hepatocytes continuously transport bile acids from portal blood into bile. This transcellular transport process is driven by Initially, elimination of compounds by the liver was stud- several active transport proteins at the basolateral and the ied using the isolated perfused rat liver. With this ex- canalicular membrane

Journal

The Journal of Membrane BiologySpringer Journals

Published: Nov 1, 1997

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