Molecular Pharmacology of Organic Cation Transporters in Kidney

Molecular Pharmacology of Organic Cation Transporters in Kidney J. Membrane Biol. 167, 103–117 (1999) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1999 Topical Review H. Koepsell, V. Gorboulev, P. Arndt Anatomisches Institut der Bayerischen Julius-Maximilians-Universita ¨t, Koellikerstr.6, 97070 Wu ¨ rzburg, Germany Received: 5 May 1998/Revised: 23 October 1998 Introduction expressed [5]. After the cloning of the first organic cat- ion transporter rOCT1 from a rat kidney library [29], an increasing number of homologous cation transporters The homeostasis of endogenous organic cations, such as 1 have been identified and it has been shown that the renal choline and N P-methylnicotinamide, monoamine neu- anion transporters also belong to this new protein family. rotransmitters, cationic drugs, such as cimetidine, mor- The functional characterization of the expressed trans- phine, quinine and amantadine, and of cationic xenobi- porters and their immunohistochemical localization in otics is controlled by reabsorption and excretion in the the kidney has begun [30–35]. This review describes the small intestine, by metabolic conversion and excretion in molecular structure of renal organic cation transporters the liver, and by reabsorption and excretion in the kidney and homologous gene products. The transport properties [1–6]. In the kidney organic cations may be ultrafiltrated and renal localization of the cloned The Journal of Membrane Biology Springer Journals

Molecular Pharmacology of Organic Cation Transporters in Kidney

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Copyright © Inc. by 1999 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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