J. Membrane Biol. 167, 103–117 (1999) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1999 Topical Review H. Koepsell, V. Gorboulev, P. Arndt Anatomisches Institut der Bayerischen Julius-Maximilians-Universita ¨t, Koellikerstr.6, 97070 Wu ¨ rzburg, Germany Received: 5 May 1998/Revised: 23 October 1998 Introduction expressed . After the cloning of the first organic cat- ion transporter rOCT1 from a rat kidney library , an increasing number of homologous cation transporters The homeostasis of endogenous organic cations, such as 1 have been identified and it has been shown that the renal choline and N P-methylnicotinamide, monoamine neu- anion transporters also belong to this new protein family. rotransmitters, cationic drugs, such as cimetidine, mor- The functional characterization of the expressed trans- phine, quinine and amantadine, and of cationic xenobi- porters and their immunohistochemical localization in otics is controlled by reabsorption and excretion in the the kidney has begun [30–35]. This review describes the small intestine, by metabolic conversion and excretion in molecular structure of renal organic cation transporters the liver, and by reabsorption and excretion in the kidney and homologous gene products. The transport properties [1–6]. In the kidney organic cations may be ultrafiltrated and renal localization of the cloned
The Journal of Membrane Biology – Springer Journals
Published: Jan 15, 1999
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera