Molecular Mechanisms in Renal and Intestinal Sulfate (Re)Absorption

Molecular Mechanisms in Renal and Intestinal Sulfate (Re)Absorption J. Membrane Biol. 181, 1–9 (2001) The Journal of DOI: 10.1007/s0023200100028 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review 1 2 M.E. Morris , H. Murer Department of Pharmaceutics, State University of New York at Buffalo, Amherst, NY, USA Institute of Physiology, University of Zu ¨ rich, Zu ¨ rich, Switzerland Received: 9 May 2000/Revised: 13 September 2000 Introduction cient intracellular pools of sulfate in chondrocytes, lead- ing to the production of undersulfated proteoglycans; the clinical features of these chondrodysplasias include Inorganic sulfate is an essential cofactor for sulfate con- dwarfism, spinal deformation and joint abnormalities jugation reactions that are responsible not only for the (Hastbacka et al., 1994). detoxification of many endogenous and exogenous com- Inorganic sulfate homeostasis is largely maintained pounds, but also for the biosynthesis of biologically ac- by reabsorption in the renal proximal tubule. Sodium- tive compounds. Xenobiotics including steroids, anti- dependent sulfate cotransport in the brush border mem- inflammatory agents, analgesics, adrenergic stimulants brane (BBM) is of primary importance in the regulation and blockers undergo biotransformation via sulfate con- of plasma inorganic sulfate concentrations. Sulfate is ac- jugation (Mulder, 1981). Sulfate conjugation is essential tively absorbed in the ileum; however the role The Journal of Membrane Biology Springer Journals

Molecular Mechanisms in Renal and Intestinal Sulfate (Re)Absorption

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Copyright © Inc. by 2001 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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