The genes encoding αl-antitrypsin (αlAT; gene symbol PI) and corticosteroid-binding globulin (CBG) are part of a cluster of structurally related serine protease inhibitor (serpin) genes on human Chromosome (Chr) 14q32.1. This cluster also includes the genes encoding αl-antichymotrypsin (AACT) and protein C inhibitor (PCI), as well as an αl-antitrypsin-related sequence (ATR; gene symbol PIL). In this report we present a detailed restriction map of a 110-kb region of genomic DNA that includes the αlAT, ATR, and CBG genes. Gene order in this interval is tel- α1AT-ATR-CBG-cen, and all three genes are transcribed in a distal-to-proximal orientation. Within the gene cluster, ATR is approximately 12 kb downstream of αlAT, and CBG is about 57 kb downstream of αlAT. Repetitive DNA sequences have been mapped throughout the interval, and several new restriction site polymorphisms in the region are described.
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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