Molecular Interaction of BMAT with Bone

Molecular Interaction of BMAT with Bone Purpose of Review Bone marrow adipose tissue (BMAT) is a distinct adipose tissue with diverse local and systemic effects, affecting both physiological processes and pathological conditions, including hematopoiesis, bone remodeling, osteoporosis, obesity, anorexia nervosa, diabetes, and cancer. BMAT increases with age and bone loss, while the significance of this phenom- enon has been neglected until recently. Bone cells and BMAT are mutually connected in terms of bone remodeling and energy metabolism. It has been suggested that high BMAT is caused by a shift in bone marrow mesenchymal stromal cell (BMSC) differentiation in favor of adipogenesis, and BMAT promotes bone loss through direct or indirect interaction with bone cells. However, it remains unclear why osteoporosis accelerates BMATaccumulation and what is the role of BMAT in bone remodeling and particularly in bone loss. The purpose of this review is to present the latest published data on the role of BMAT in physiological bone processes and during osteoporosis progression. Recent Findings BMAT secretes numerous endocrine factors designated as adipokines as well as pro-inflammatory cytokines, which affect bone homeostasis through the regulation of osteoblast and osteoclast function. Most clinical data from osteoporotic patients demonstrate a negative relationship between BMAT and bone mass. Through http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Molecular Biology Reports Springer Journals

Molecular Interaction of BMAT with Bone

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Molecular Medicine; Human Genetics
eISSN
2198-6428
D.O.I.
10.1007/s40610-018-0093-y
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Bone marrow adipose tissue (BMAT) is a distinct adipose tissue with diverse local and systemic effects, affecting both physiological processes and pathological conditions, including hematopoiesis, bone remodeling, osteoporosis, obesity, anorexia nervosa, diabetes, and cancer. BMAT increases with age and bone loss, while the significance of this phenom- enon has been neglected until recently. Bone cells and BMAT are mutually connected in terms of bone remodeling and energy metabolism. It has been suggested that high BMAT is caused by a shift in bone marrow mesenchymal stromal cell (BMSC) differentiation in favor of adipogenesis, and BMAT promotes bone loss through direct or indirect interaction with bone cells. However, it remains unclear why osteoporosis accelerates BMATaccumulation and what is the role of BMAT in bone remodeling and particularly in bone loss. The purpose of this review is to present the latest published data on the role of BMAT in physiological bone processes and during osteoporosis progression. Recent Findings BMAT secretes numerous endocrine factors designated as adipokines as well as pro-inflammatory cytokines, which affect bone homeostasis through the regulation of osteoblast and osteoclast function. Most clinical data from osteoporotic patients demonstrate a negative relationship between BMAT and bone mass. Through

Journal

Current Molecular Biology ReportsSpringer Journals

Published: Mar 28, 2018

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