Curr Neurol Neurosci Rep (2017) 17: 73 DOI 10.1007/s11910-017-0789-z NEUROIMAGING (N PAVESE, SECTION EDITOR) Molecular Imaging and Updated Diagnostic Criteria in Lewy Body Dementias 1 1,2 1,3 Nicolaas I. Bohnen & Martijn L. T. M. Müller & Kirk A. Frey Published online: 14 August 2017 Springer Science+Business Media, LLC 2017 Abstract Alzheimer disease (AD; highest). However, tau binding in Purpose of Review The aims of the study were to review DLB, including the medial temporal lobe, is substantially low- recent advances in molecular imaging in the Lewy body de- er than in AD. mentias (LBD) and determine if these may support the clinical Summary Alzheimer-type proteinopathies appear to be more but contested temporal profile distinction between Parkinson common in DLB compared to PDD with relative but no ab- disease (PD) with dementia (PDD) versus dementia with solute differences. Given the spectrum of overlapping pathol- Lewy bodies (DLB). ogies, future α-synuclein ligands are expected to have the best Recent Findings There do not appear to be major regional potential to distinguish the LBD from pure AD. cerebral metabolic or neurotransmitter distinctions between . . PDD and DLB. However, recent studies highlight the relative Keywords Acetylcholine β-Amyloid DementiawithLewy . . .
Current Neurology and Neuroscience Reports – Springer Journals
Published: Aug 14, 2017
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