Molecular evolution of the VP7 gene of Japanese G2 rotaviruses before vaccine introduction

Molecular evolution of the VP7 gene of Japanese G2 rotaviruses before vaccine introduction Changes in the prevalence of G2 rotavirus after vaccine introduction are an important issue. However, such changes in a given country should be interpreted in the global context over time. We determined 35 Japanese G2 sequences and compared them with 508 globally collected G2 sequences. The D96N substitution, a substitution known to be associated with an abrupt increase in G2 strains and antigenic changes, emerged in those strains that formed a nascent lineage outside of the currently predominant lineage (sublineage IVa). Further studies are warranted to monitor the potential of their global spread, since they also appeared in Europe and Australia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Molecular evolution of the VP7 gene of Japanese G2 rotaviruses before vaccine introduction

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1804-6
Publisher site
See Article on Publisher Site

Abstract

Changes in the prevalence of G2 rotavirus after vaccine introduction are an important issue. However, such changes in a given country should be interpreted in the global context over time. We determined 35 Japanese G2 sequences and compared them with 508 globally collected G2 sequences. The D96N substitution, a substitution known to be associated with an abrupt increase in G2 strains and antigenic changes, emerged in those strains that formed a nascent lineage outside of the currently predominant lineage (sublineage IVa). Further studies are warranted to monitor the potential of their global spread, since they also appeared in Europe and Australia.

Journal

Archives of VirologySpringer Journals

Published: Feb 1, 2014

References

  • Molecular characterization of VP7 gene of human rotaviruses from Bangladesh
    Ahmed, K; Ahmed, S; Mitui, MT; Rahman, A; Kabir, L; Hannan, A; Nishizono, A; Nakagomi, O
  • The occurrence of amino acid substitutions D96N and S242N in VP7 of emergent G2P(4) rotaviruses in Nepal in 2004–2005: a global and evolutionary perspective
    Doan, YH; Nakagomi, T; Cunliffe, NA; Pandey, BD; Sherchand, JB; Nakagomi, O
  • Apparent extinction of non-G2 rotavirus strains from circulation in Recife, Brazil, after the introduction of rotavirus vaccine
    Nakagomi, T; Cuevas, LE; Gurgel, RG; Elrokhsi, SH; Belkhir, YA; Abugalia, M; Dove, W; Montenegro, FM; Correia, JB; Nakagomi, O; Cunliffe, NA; Hart, CA

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