Molecular epidemiology of hepatitis C virus among different groups of people in the province of Fujian, China

Molecular epidemiology of hepatitis C virus among different groups of people in the province of... Genotyping of hepatitis C virus (HCV) can provide valuable information for prognosis and treatment duration prediction. To explore the genetic diversity of HCV in Fujian Province, China, 112, 104 and 48 anti-HCV-positive serum samples were collected from volunteer blood donors, IDUs and patients, respectively, from Jan 2008 to Dec 2008 and were genotyped through sequence analysis, followed by phylogenetic analysis in the C/E1 and NS5B regions. Genotypes could be determined for 85.61 and 84.85 % of samples in the C/E1 and NS5B region, respectively. 6a was the most prevalent subtype, which accounted for 42.04 and 43.75 % in the C/E1 and NS5B region, respectively. Mixed infection and potential recombination were detected in this study. Kappa tests indicated that similar results were obtained by two genotyping methods targeting the C/E1 and NS5B regions. The differences in the main prevalent subtype between the three target groups suggest diversity of HCV prevalence in different populations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Molecular epidemiology of hepatitis C virus among different groups of people in the province of Fujian, China

Loading next page...
 
/lp/springer_journal/molecular-epidemiology-of-hepatitis-c-virus-among-different-groups-of-bp2yZdp0Qs
Publisher
Springer Vienna
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-012-1513-6
Publisher site
See Article on Publisher Site

Abstract

Genotyping of hepatitis C virus (HCV) can provide valuable information for prognosis and treatment duration prediction. To explore the genetic diversity of HCV in Fujian Province, China, 112, 104 and 48 anti-HCV-positive serum samples were collected from volunteer blood donors, IDUs and patients, respectively, from Jan 2008 to Dec 2008 and were genotyped through sequence analysis, followed by phylogenetic analysis in the C/E1 and NS5B regions. Genotypes could be determined for 85.61 and 84.85 % of samples in the C/E1 and NS5B region, respectively. 6a was the most prevalent subtype, which accounted for 42.04 and 43.75 % in the C/E1 and NS5B region, respectively. Mixed infection and potential recombination were detected in this study. Kappa tests indicated that similar results were obtained by two genotyping methods targeting the C/E1 and NS5B regions. The differences in the main prevalent subtype between the three target groups suggest diversity of HCV prevalence in different populations.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2013

References

  • Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
    Simmonds, P; Bukh, J; Combet, C
  • Transfusion transmission of HCV infection before anti-HCV testing of blood donations in England: results of the national HCV lookback program
  • Preliminary data for genotype distribution and epidemiological aspects of hepatitis C virus infection in blood donors from Yucatan, Mexico
    Garcia-Montalvo, BM; Macossay-Castillo, M
  • Investigation of the pattern of diversity of hepatitis C virus in relation to times of transmission
    Simmonds, P; Smith, DB
  • The future for the treatment of genotype 4 chronic hepatitis C
    Esmat, G; EI Raziky, M; EI Kassas, M; Hassany, M; Gamil, ME
  • The neglected hepatitis C virus genotypes 4, 5 and 6: an international consensus report
    Antaki, N; Craxi, A; Kamal, S
  • MEGA2: molecular evolutionary genetics analysis software
    Kumar, S; Tamura, K; Jakobsen, IB; Nei, M
  • Analysis of true voluntary blood donors with anti-HCV prevalence and implications for donor management in Chongqing
    Zhao, SM; Jiang, TL; Gao, FX

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off