& Morteza Shiri email@example.com & Majid M. Heravi firstname.lastname@example.org Department of Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa 123 2120 V. Zadsirjan et al. Keywords Ugi reaction Aroylacrylic acids Base catalysis Intramolecular Michael addition 2,5-Diketopiperazines Molecular diversity Density functional theory Quantum theory of atoms in molecules Polarized continuum model Antibacterial and antifungal activities Introduction The 2,5-Diketopiperazines (2,5-DKPs), cyclodipeptides can be prepared by the reaction of two a-amino acids. They are found in nature, and are usually created from the degradation of polypeptides found in beverages and processed food. They are present in various bacteria, fungi, mammals and the plant kingdom. For example, 2,5-DKPs abound in the structure of numerous natural products such as okaramine N , dysamide B , FR106969  and citreoindole  (Fig. 1). Due to the ability of 2,5-diketopiperazines to bind to a number of receptors, they can be considered as attractive scaffolds in drug discovery. In these small heterocyclic molecules, it is possible to have a number of stereocenters to create diverse structures. Several reviews on the synthesis of natural products containing
Research on Chemical Intermediates – Springer Journals
Published: Oct 11, 2016
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