Molecular detection of human parechovirus in children with acute gastroenteritis in Guangzhou, China

Molecular detection of human parechovirus in children with acute gastroenteritis in Guangzhou, China Human parechoviruses (HPeVs) are widespread pathogens causing a wide spectrum of diseases. The prevalence and genetic diversity of HPeV in children with acute diarrhea in China is not well known. The purpose of this study was to investigate the epidemiological characteristics of HPeV in Guangzhou, China. A total of 328 stool specimens collected from children under the age of 5 years with acute diarrhea were tested for the presence of HPeV. Of these, 44 (13.4 %, 44/328) were HPeV positive, with the majority of the infected children (97.7 %, 43/44) being younger than two years of age. HPeV was more frequently detected during July and August. The epidemiological profile of co-infections was similar to that observed in a previous study. Six different HPeV genotypes, including HPeV1, -3, -4, -5, -6, and -14, were identified, and of these, HPeV14, a rarely reported genotype, was reported for the first time in children with acute gastroenteritis in China. In summary, this study clearly demonstrated that HPeV circulating in Guangzhou, China, is genetically diverse, including six genotypes, and it provides useful epidemiological data on the features of HPeV infection in this area. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Molecular detection of human parechovirus in children with acute gastroenteritis in Guangzhou, China

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1915-0
Publisher site
See Article on Publisher Site

Abstract

Human parechoviruses (HPeVs) are widespread pathogens causing a wide spectrum of diseases. The prevalence and genetic diversity of HPeV in children with acute diarrhea in China is not well known. The purpose of this study was to investigate the epidemiological characteristics of HPeV in Guangzhou, China. A total of 328 stool specimens collected from children under the age of 5 years with acute diarrhea were tested for the presence of HPeV. Of these, 44 (13.4 %, 44/328) were HPeV positive, with the majority of the infected children (97.7 %, 43/44) being younger than two years of age. HPeV was more frequently detected during July and August. The epidemiological profile of co-infections was similar to that observed in a previous study. Six different HPeV genotypes, including HPeV1, -3, -4, -5, -6, and -14, were identified, and of these, HPeV14, a rarely reported genotype, was reported for the first time in children with acute gastroenteritis in China. In summary, this study clearly demonstrated that HPeV circulating in Guangzhou, China, is genetically diverse, including six genotypes, and it provides useful epidemiological data on the features of HPeV infection in this area.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2014

References

  • Human parechoviruses–biology and clinical significance
    Stanway, G; Joki-Korpela, P; Hyypia, T
  • Detection of human parechoviruses in children with gastroenteritis in South Korea
    Han, TH; Kim, CH; Park, SH; Chung, JY; Hwang, ES
  • Prevalence of human parechovirus in Chinese children hospitalized for acute gastroenteritis
    Zhang, DL; Jin, Y; Li, DD; Cheng, WX; Xu, ZQ
  • Detection of norovirus (GI, GII), Sapovirus and astrovirus in fecal samples using reverse transcription single-round multiplex PCR
    Yan, H; Yagyu, F; Okitsu, S; Nishio, O; Ushijima, H
  • Detection and identification of human parechoviruses from clinical specimens
    Chen, BC; Cheng, MF; Huang, TS; Liu, YC; Tang, CW
  • Detection of human enterovirus and human parechovirus (HPeV) genotypes from clinical stool samples: polymerase chain reaction and direct molecular typing, culture characteristics, and serotyping
    Benschop, K; Minnaar, R; Koen, G; Eijk, H; Dijkman, K

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