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T. Bach (1987)
Synthesis and metabolism of mevalonic acid in plantsPlant Physiology and Biochemistry, 25
A. Bostock, B. Stermer (1989)
Perspectives on Wound Healing in Resistance to PathogensAnnual Review of Phytopathology, 27
CJ Denbow, S Lång, CL Cramer (1996)
The N-terminal domain of tomato 3-hydroxy-3-methylglutaryl-CoA reductases. Sequence, microsomal targeting and glycosylationJ Biol Chem, 271
R. Burnett, I. Maldonado-Mendoza, T. McKnight, C. Nessler (1993)
Expression of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene from Camptotheca acuminata Is Differentially Regulated by Wounding and Methyl Jasmonate, 103
B. Stermer, G. Bianchini, K. Korth, Stermer, G. Bianchini, K. Korth, Regula (1994)
Regulation of HMG-CoA reductase activity in plants.Journal of lipid research, 35 7
R. Aerts, Daniel Gisi, E. Carolis, V. Luca, Thomas Baumann (1994)
Methyl jasmonate vapor increases the developmentally controlled synthesis of alkaloids in Catharanthus and Cinchona seedlingsPlant Journal, 5
AJ van Hengel, MP Harkes, HJ Wichers, PGM Hesselink (1992)
Buitelaar RM: Characterization of callus formation and camptothecin production by cell lines of Camptotheca acuminataPlant Cell Tissue Organ Cult, 28
C. Li, C. Wang, A. Pardee (1994)
Camptothecin inhibits Tat-mediated transactivation of type 1 human immunodeficiency virus.The Journal of biological chemistry, 269 10
M. Chye, Chio-Tee Tan, N. Chua (1992)
Three genes encode 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hevea brasiliensis: hmg1 and hmg3 are differentially expressedPlant Molecular Biology, 19
Zhenbiao Yang, Heesung Park, George Lacy, Carole Cramer (1991)
Differential activation of potato 3-hydroxy-3-methylglutaryl coenzyme A reductase genes by wounding and pathogen challenge.The Plant cell, 3
A. Hengel, M. Harkes, H. Wichers, P. Hesselink, R. Buitelaar (2004)
Characterization of callus formation and camptothecin production by cell lines of Camptotheca acuminataPlant Cell, Tissue and Organ Culture, 28
IE Maldonado-Mendoza, RJ Burnett, CL Nessler (1992)
Nucleotide sequence of a cDNA encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Catharanthus roseusPlant Physiol, 100
Joseph Chappell (1995)
The Biochemistry and Molecular Biology of Isoprenoid Metabolism, 107
(1982)
Isolation of plant DNA and RNA
I. Maldonado-Mendoza, R. Burnett, M. López-Meyer, C. Nessler (1994)
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by wounding and methyl jasmonatePlant Cell, Tissue and Organ Culture, 38
Paulo Moreno, R. Heijden, R. Verpoorte (1993)
Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseusPlant Cell Reports, 12
A. Jain, C. Nessler (1996)
Clonal propagation of Camptotheca acuminata through shoot bud culturePlant Cell, Tissue and Organ Culture, 44
ML Chye, CT Tan, NH Chua (1992)
Three genes encode 3-hydroxy-3-methyl glutaryl-coenzymeAreductase in Hevea brasiliensis: hmg1and hmg3are differentially expressedPlantMol Biol, 19
C. Denbow, Saara Lång, C. Cramer (1996)
The N-terminal Domain of Tomato 3-Hydroxy-3-methylglutaryl-CoA ReductasesThe Journal of Biological Chemistry, 271
H. Gundlach, M. Müller, T. Kutchan, M. Zenk (1992)
Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures.Proceedings of the National Academy of Sciences of the United States of America, 89 6
M. Basson, M. Thorsness, J. Rine (1986)
Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Proceedings of the National Academy of Sciences of the United States of America, 83 15
D. Monger, W. Lim, F. Kézdy, J. Law (1982)
Compactin inhibits insect HMG-CoA reductase and juvenile hormone biosynthesis.Biochemical and biophysical research communications, 105 4
N. Campos, A. Boronat (1995)
Targeting and topology in the membrane of plant 3-hydroxy-3-methylglutaryl coenzyme A reductase.The Plant cell, 7
T. Murashige, F. Skoog (1962)
A revised medium for rapid growth and bio assays with tobacco tissue culturesPhysiologia Plantarum, 15
E. Priel, S. Showalter, M. Roberts, S. Oroszlan, D. Blair (1991)
The topoisomerase I inhibitor, camptothecin, inhibits equine infectious anemia virus replication in chronically infected CF2Th cellsJournal of Virology, 65
J. Narita, Wilhelm Gruissem (1989)
Tomato hydroxymethylglutaryl-CoA reductase is required early in fruit development but not during ripening.The Plant cell, 1
D. Dagnino, J. Schripsema, R. Verpoorte (1995)
Terpenoid indole alkaloid biosynthesis and enzyme activities in two cell lines of Tabernaemontana divaricataPhytochemistry, 39
(1996)
Isolation and characterization of two differentially regulated tryptophan decarboxylase (TDC) genes from Camptotheca acuminata (Decaisne)
IE Maldonado-Mendoza, RJ Burnett, M López-Meyer, CL Nessler (1994)
Regulation of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase by wounding and methyl jasmonate: Implications for the production of anti-cancer alkaloidsPlant Cell Tiss Organ Cult, 38
J. Mérillon, Lazhar Ouelhazii, P. Doireau, J. Chénieux, M. Rideau (1989)
Metabolic Changes and Alkaloid Production in Habituated and Non-habituated Cells of Catharanthus roseus Grown in Hormone-free Medium. Comparing Hormone-deprived Non-habituated Cells with Habituated CellsJournal of Plant Physiology, 134
J. Goldstein, Michael Brown (1990)
Regulation of the mevalonate pathwayNature, 343
I. Maldonado-Mendoza, R. Burnett, C. Nessler (1992)
Plant GeneRegister Nucleotide Sequence ofa cDNA Encoding 3-Hydroxy-3-Methylglutaryl CoenzymeA Reductase from Catharanthus roseus'
U. Eilert, V. Luca, F. Constabel, W. Kurz (1987)
Elicitor-mediated induction of tryptophan decarboxylase and strictosidine synthase activities in cell suspension cultures of Catharanthus roseus.Archives of biochemistry and biophysics, 254 2
M. López-Meyer, C. Nessler, T. McKnight (1994)
Sites of Accumulation of the Antitumor Alkaloid Camptothecin in Camptotheca acuminataPlanta Medica, 60
D. Choi, B. Ward, R. Bostock (1992)
Differential induction and suppression of potato 3-hydroxy-3-methylglutaryl coenzyme A reductase genes in response to Phytophthora infestans and to its elicitor arachidonic acid.The Plant cell, 4
AK Jain, CL Nessler (1996)
Clonal propagation of Camptotheca acuminatathrough shoot bud culturePlant Cell Rep, 44
E. Priel, S. Showalter, D. Blair (1991)
Inhibition of human immunodeficiency virus (HIV-1) replication in vitro by noncytotoxic doses of camptothecin, a topoisomerase I inhibitor.AIDS research and human retroviruses, 7 1
Eigil Kjeldsen, Jesper Svejstrup, Irina Gromova, Jan Alsner, Ole Westergaard (1992)
Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I.Journal of molecular biology, 228 4
A. Bodley, T. Shapiro (1995)
Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania.Proceedings of the National Academy of Sciences of the United States of America, 92
Camptotheca acuminata is a Chinese tree that produces the anti-cancer monoterpenoid indole alkaloid camptothecin (CPT). 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) supplies mevalonate for the terpenoid moiety of CPT and its hydroxylated derivative 10-hydroxycamptothecin (10-OH-CPT). We previously described the isolation of a gene encoding HMGR from C. acuminata (hmg1) and analyzed its expression in transgenic tobacco [6]. Here, we report on the isolation of genomic (hmg2) and cDNA (hmg3) clones representing two additional HMGR gene family members and characterize the expression of all three genes in C. acuminata. Transcript levels for two family members were highest in the shoot apex, dry seeds (hmg1), and bark (hmg3) which are the tissues containing the highest levels of CPT and 10-OH-CPT respectively. Levels of hmg3 mRNA also correlated with the accumulation of 10-OH-CPT during germination. In C. acuminata leaf disks, hmg1 mRNA increased in response to wounding, and this induction was suppressed by methyl jasmonate (MeJA), in agreement with results previously obtained in transgenic tobacco [6]. In contrast, wounding and MeJA did not affect hmg2 or hmg3 transcript levels in C. acuminata. These results show that members of the C. acuminata HMGR gene family are differentially expressed in various tissues under different physiological conditions which may contribute to the regulation of monoterpenoid indole alkaloid synthesis in this species.
Plant Molecular Biology – Springer Journals
Published: Sep 29, 2004
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