Molecular characterization of rare G12P(6) rotavirus isolates closely related to G12 strains from the United States, CAU 195 and CAU 214

Molecular characterization of rare G12P(6) rotavirus isolates closely related to G12 strains from... Two human G12 rotaviruses, CAU 195 and CAU 214, were isolated from South Korea using cell culture and characterized on the basis of sequence divergence in the VP7 , VP4 , and NSP4 genes. Phylogenetic analysis of the VP7 gene sequences indicated that these strains clustered into lineage III and were most closely related to G12 rotaviruses isolated in the United States. The VP4 and NSP4 gene sequences showed that two strains belonged to the P(6)-Ia lineage and genotype (B). This finding provides information that can be used to evaluate G12 strains and aid in the development of effective vaccines in the future. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Molecular characterization of rare G12P(6) rotavirus isolates closely related to G12 strains from the United States, CAU 195 and CAU 214

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Biomedicine; Virology ; Medical Microbiology ; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-010-0865-z
Publisher site
See Article on Publisher Site

Abstract

Two human G12 rotaviruses, CAU 195 and CAU 214, were isolated from South Korea using cell culture and characterized on the basis of sequence divergence in the VP7 , VP4 , and NSP4 genes. Phylogenetic analysis of the VP7 gene sequences indicated that these strains clustered into lineage III and were most closely related to G12 rotaviruses isolated in the United States. The VP4 and NSP4 gene sequences showed that two strains belonged to the P(6)-Ia lineage and genotype (B). This finding provides information that can be used to evaluate G12 strains and aid in the development of effective vaccines in the future.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2011

References

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