Molecular characterization of group A rotavirus strains detected in children with diarrhea admitted to Nigerian hospitals in 2013

Molecular characterization of group A rotavirus strains detected in children with diarrhea... Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in children worldwide and cause up to 455,000 deaths annually, mostly in developing countries. During 2013, 66 RVAs from children with AGE admitted to four Nigerian hospitals were investigated. The G3P(6), G1P(8) and G2P(4) genotypes predominated. The VP7 and/or VP4 genes of 18 G3P(6)/(8)/(4), six G2P(4), three G12P(8)/(4), and two G1P(8) RVA strains were sequenced. The G3P(6) strains belonged to lineage G3-III and were different from G3 strains widespread in Asia. Phylogenetic analysis revealed substantial sequence conservation, suggesting continuing evolution and genomic reassortment but no zoonotic RVA transmission from animals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Molecular characterization of group A rotavirus strains detected in children with diarrhea admitted to Nigerian hospitals in 2013

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2389-z
Publisher site
See Article on Publisher Site

Abstract

Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in children worldwide and cause up to 455,000 deaths annually, mostly in developing countries. During 2013, 66 RVAs from children with AGE admitted to four Nigerian hospitals were investigated. The G3P(6), G1P(8) and G2P(4) genotypes predominated. The VP7 and/or VP4 genes of 18 G3P(6)/(8)/(4), six G2P(4), three G12P(8)/(4), and two G1P(8) RVA strains were sequenced. The G3P(6) strains belonged to lineage G3-III and were different from G3 strains widespread in Asia. Phylogenetic analysis revealed substantial sequence conservation, suggesting continuing evolution and genomic reassortment but no zoonotic RVA transmission from animals.

Journal

Archives of VirologySpringer Journals

Published: Jun 1, 2015

References

  • Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen
    Hu, L; Crawford, SE; Czako, R; Cortes-Penfield, NW; Smith, DF; Pendu, J; Estes, MK; Prasad, BV
  • Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine
    Santos, N; Hoshino, Y

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