Molecular characterization of cell types in the developing, mature, and regenerating fish retina

Molecular characterization of cell types in the developing, mature, and regenerating fish retina The fish retina has become a powerful model system for the study of different aspects of development and regeneration. An important aspect in understanding retinal anatomy and function is to trace the development of various cell types during embryonic stages. Several markers that detect the cessation of proliferative activity have been used in studies of cellular birth days, in order to follow the temporal progression of retinogenesis. Moreover, by using cell type-specific markers, the onset of differentiation can be determined by identifying the earliest time points for which immunolabeling is observed. Additionally, fish retinal regeneration research holds the potential of providing new avenues for the treatment of degenerative diseases of the retina. Retinal markers constitute powerful tools in studies of retinal regeneration, because they allow characterization of the cell types involved in nerve tissue regeneration, providing insights into different aspects of this process. In this review, after presenting several structural and histological aspects of the mature and developing fish visual system, data on the use of various neurochemical markers specifically indicating cell types of the fish neural retina are summarized. This will be done through a review of the pertinent literature, as well as by drawing on our own experience gathered through recent studies on fish retinogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reviews in Fish Biology and Fisheries Springer Journals

Molecular characterization of cell types in the developing, mature, and regenerating fish retina

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Publisher
Springer International Publishing
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Life Sciences; Freshwater & Marine Ecology; Zoology
ISSN
0960-3166
eISSN
1573-5184
D.O.I.
10.1007/s11160-013-9320-z
Publisher site
See Article on Publisher Site

Abstract

The fish retina has become a powerful model system for the study of different aspects of development and regeneration. An important aspect in understanding retinal anatomy and function is to trace the development of various cell types during embryonic stages. Several markers that detect the cessation of proliferative activity have been used in studies of cellular birth days, in order to follow the temporal progression of retinogenesis. Moreover, by using cell type-specific markers, the onset of differentiation can be determined by identifying the earliest time points for which immunolabeling is observed. Additionally, fish retinal regeneration research holds the potential of providing new avenues for the treatment of degenerative diseases of the retina. Retinal markers constitute powerful tools in studies of retinal regeneration, because they allow characterization of the cell types involved in nerve tissue regeneration, providing insights into different aspects of this process. In this review, after presenting several structural and histological aspects of the mature and developing fish visual system, data on the use of various neurochemical markers specifically indicating cell types of the fish neural retina are summarized. This will be done through a review of the pertinent literature, as well as by drawing on our own experience gathered through recent studies on fish retinogenesis.

Journal

Reviews in Fish Biology and FisheriesSpringer Journals

Published: Aug 2, 2013

References

  • Presence and development of thyrotropin-releasing hormone-immunoreactive amacrine cells in the retina of a teleost, the brown trout (Salmo trutta fario)
    Anadón, R; Becerra, M; Díaz, ML
  • Comparative investigations of the neuronal apparatus in the pineal organ and retina of the rainbow trout: immunocytochemical demonstration of neurofilament 200-kDa and neuropeptide Y, and tracing with DiI
    Blank, H; Muller, B; Korf, H
  • Morphogenesis in the retina of a slow-developing teleost: emergence of the GABAergic system in relation to cell proliferation and differentiation
    Candal, E; Ferreiro-Galve, S; Anadón, R
  • Temporal and spatial organization of tyrosine hydroxylase-immunoreactive cell groups in the embryonic brain of an elasmobranch, the lesser-spotted dogfish Scyliorhinus canicula
    Carrera, I; Sueiro, C; Molist, P
  • Early eye development in vertebrates
    Chow, RL; Lang, RA
  • Onset of synaptogenesis in the plexiform layers of the chick retina: a transmission electron microscopic study
    Drenhaus, U; Voigt, T; Rager, G

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