Molecular basis of pituitary dysfunction in mouse and human

Molecular basis of pituitary dysfunction in mouse and human Review Incorporating Mouse Genome Mammalian Genome 12, 485–494 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s003350040002 Lisa J. Cushman, Sally A. Camper Department of Human Genetics, 4301 MSRBIII, 1500 W. Medical Center Drive, University of Michigan Medical School, Ann Arbor, Michigan 48109-0638, USA Received: 20 December 2000/ Accepted: 5 February 2001 The pituitary gland functions as an intermediary between the brain the process of pituitary gland organogenesis has been described in and the peripheral endocrine organs of the body (Tortora and recent years (Table 1). Homeobox genes critical for the develop- Grabowski 1996). In the context of a complex system of feedback ment of the anterior pituitary include the LIM homeodomain tran- control, the pituitary gland relays signals from the hypothalamus to scription factor Lhx3, the ‘paired’-like homeodomain transcription its target organs by secreting various hormones. These hormone factors Hesx1 (also known as Rathke’s pouch homeobox or Rpx) signals, which are transmitted throughout the endocrine system, and Prop1, and the POU homeodomain transcription factor Pit1 reflect the current homeostatic conditions of the body. Mecha- (Li et al. 1990; Sheng et al. 1996; Sornson et al. 1996; Dattani et nisms of compensation, including the regulation of gene transcrip- al. Mammalian Genome Springer Journals

Molecular basis of pituitary dysfunction in mouse and human

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Copyright © 2001 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
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