Molecular and serological evidence for Seoul virus in rats ( Rattus norvegicus ) in Zhangmu, Tibet, China

Molecular and serological evidence for Seoul virus in rats ( Rattus norvegicus ) in Zhangmu,... We report the detection of a virus, tentatively identified as Seoul virus (SEOV), from a rat ( Rattus norvegicus ) collected in the city of Zhangmu, Tibet. SEOV RNA was detected in lung tissue by reverse transcription (RT)-PCR, followed by sequencing. Serum samples collected from Zhangmu were positive for SEOV-specific antibodies (indirect fluorescent antibody test that used SEO antigen). Sequencing and phylogenetic analysis of partial L and S sequences together with serology results suggest that the Zhangmu01 hantavirus is an isolate of SEOV, that hantaviruses circulate in Tibet, and that rats may act as natural reservoirs for the virus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Molecular and serological evidence for Seoul virus in rats ( Rattus norvegicus ) in Zhangmu, Tibet, China

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2391-5
Publisher site
See Article on Publisher Site

Abstract

We report the detection of a virus, tentatively identified as Seoul virus (SEOV), from a rat ( Rattus norvegicus ) collected in the city of Zhangmu, Tibet. SEOV RNA was detected in lung tissue by reverse transcription (RT)-PCR, followed by sequencing. Serum samples collected from Zhangmu were positive for SEOV-specific antibodies (indirect fluorescent antibody test that used SEO antigen). Sequencing and phylogenetic analysis of partial L and S sequences together with serology results suggest that the Zhangmu01 hantavirus is an isolate of SEOV, that hantaviruses circulate in Tibet, and that rats may act as natural reservoirs for the virus.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2015

References

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