Molecular and immunologic characterization of group A bovine rotavirus field isolates with P8(11) spike protein

Molecular and immunologic characterization of group A bovine rotavirus field isolates with P8(11)... Bovine rotavirus strain B223 is the North American prototype for group A P8(11) serotype/genotype rotaviruses. Rotaviruses with this serotype/genotype are a prevalent cause of neonatal calf diarrhea and have also been isolated from asymptomatic human infants. On the basis of deduced amino acid sequence of the outer capsid viral protein 4 (VP4), strain B223 lacks a cysteine at position 318 that is conserved among all other rotavirus strains. It has been speculated that this may result in the loss of disulfide bond and a change in the structure of the VP4 that may affect the infectivity and antigenicity of the virus. This paper describes partial sequences of the VP4 gene (nucleotides 613 to 1 016 coding for amino acid positions 202 to 335) of 16 bovine rotavirus field isolates with P8(11) that were obtained from calves in Nebraska and Indiana. All the isolates lack a cystein at position 203 and had a conserved valine residue at position 318, thus indicating that the prototype strain B223 is representative of group A rotaviruses with P8(11) serotype/genotype. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Molecular and immunologic characterization of group A bovine rotavirus field isolates with P8(11) spike protein

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Publisher
Springer Journals
Copyright
Copyright © Wien by 1998 Springer-Verlag/
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050050351
Publisher site
See Article on Publisher Site

Abstract

Bovine rotavirus strain B223 is the North American prototype for group A P8(11) serotype/genotype rotaviruses. Rotaviruses with this serotype/genotype are a prevalent cause of neonatal calf diarrhea and have also been isolated from asymptomatic human infants. On the basis of deduced amino acid sequence of the outer capsid viral protein 4 (VP4), strain B223 lacks a cysteine at position 318 that is conserved among all other rotavirus strains. It has been speculated that this may result in the loss of disulfide bond and a change in the structure of the VP4 that may affect the infectivity and antigenicity of the virus. This paper describes partial sequences of the VP4 gene (nucleotides 613 to 1 016 coding for amino acid positions 202 to 335) of 16 bovine rotavirus field isolates with P8(11) that were obtained from calves in Nebraska and Indiana. All the isolates lack a cystein at position 203 and had a conserved valine residue at position 318, thus indicating that the prototype strain B223 is representative of group A rotaviruses with P8(11) serotype/genotype.

Journal

Archives of VirologySpringer Journals

Published: Apr 1, 1998

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