Molecular analysis of the Y chromosome in XX sex-reversed patients

Molecular analysis of the Y chromosome in XX sex-reversed patients Molecular genetic analysis was performed for 26 phenotypically male patients lacking the Y chromosome in the karyotype. The sex-determining region Y (SRY) gene was found in 77% of the patients. PCR analysis of Y-specific loci in the 17 SRY-positive patients revealed Yp fragments varying in size in 16 cases and cryptic mosaicism (or chimerism) for the Y chromosome in one case. The frequencies of class I, II, and III (Yp+)XX sex reversals were 18.75, 25.25, and 56%, respectively. All of the class III (Yp+)XX sex-reversed patients had a 3.5-Mb paracentric inversion flanked by inverted repeats 3 (IR3) on the short arm of the Y chromosome. Russian Journal of Genetics Springer Journals

Molecular analysis of the Y chromosome in XX sex-reversed patients

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SP MAIK Nauka/Interperiodica
Copyright © 2008 by Pleiades Publishing, Ltd.
Biomedicine; Microbial Genetics and Genomics; Human Genetics ; Animal Genetics and Genomics
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