Molecular Analyses of Tight Junction Physiology: Insights and Paradoxes

Molecular Analyses of Tight Junction Physiology: Insights and Paradoxes J. Membrane Biol. 163, 159–167 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review 1 2 3 A.S. Yap , J.M. Mullin , B.R. Stevenson Department of Physiology & Pharmacology, The University of Queensland, St. Lucia, Australia 4072 Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096–411, USA Department of Cell Biology and Anatomy, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7 Received: 30 September 1997/Revised: 25 November 1997 Introduction properties of epithelia and the ultrastructural appearance of the tight junction, it has been hypothesized that the tight junction contains size- and charge-selective aque- Epithelia and endothelia demarcate and regulate trans- ous channels or pores formed by integral membrane pro- port between tissue compartments in the body. The tight teins that otherwise act to occlude the extracellular space junction contributes to two central aspects of epithelial (Cereijido et al., 1989; Madara et al., 1992; Reuss, 1992). and endothelial physiology. First, the tight junction con- Such channels would allow the selective passage of ions, stitutes the principal barrier to passive movement of but not macromolecules or cells. In addition, it has been fluid, electrolytes, macromolecules and cells through the proposed that continuous chains of these integral mem- The Journal of Membrane Biology Springer Journals

Molecular Analyses of Tight Junction Physiology: Insights and Paradoxes

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Copyright © Inc. by 1998 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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