The modulation of I A K+ current by ten trivalent lanthanide (Ln3+) cations spanning the series with ionic radii ranging from 0.99 Å to 1.14 Å was characterized by the whole-cell patch clamp technique in bovine adrenal zona fasciculata (AZF) cells. Each of the ten Ln3+s reduced I A amplitude measured at +20 mV in a concentration-dependent manner. Smaller Ln3+s were the most potent and half-maximally effective concentrations (EC50s) varied inversely with ionic radius for the larger elements. Estimation of EC50s yielded the following potency sequence: Lu3+ (EC50= 3.0 μm) ≈ Yb3+ (EC50= 2.7 μm) > Er3+ (EC50= 3.7 μm) ≥ Dy3+ (EC50= 4.7 μm) > Gd3+ (EC50= 6.7 μm) ≈ Sm3+ (EC50= 6.9 μm) > Nd3+ (EC50= 11.2 μm) > Pr3+ (EC50= 22.3 μm) > Ce3+ (EC50= 28.0 μm) > La3+ (EC50= 33.7 μm).
The Journal of Membrane Biology – Springer Journals
Published: Jul 15, 1998
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