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T. Sharifnia, J. Antoun, Thomas Verriere, G. Suarez, J. Wattacheril, K. Wilson, R. Peek, N. Abumrad, C. Flynn (2015)
Hepatic TLR4 signaling in obese NAFLD.American journal of physiology. Gastrointestinal and liver physiology, 309 4
L. Mckay, J. Cidlowski (1999)
Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways.Endocrine reviews, 20 4
HJ Kim, KG Park, EK Yoo, YH Kim, YN Kim, HS Kim, HT Kim, JY Park, KU Lee, WG Jang, JG Kim, BW Kim, IK Lee (2007)
Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cellsAntioxid Redox Signal, 9
Y. Marchand-Brustel, P. Gual, T. Grémeaux, T. Gonzalez, R. Barrès, J. Tanti (2003)
Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling.Biochemical Society transactions, 31 Pt 6
Fabrice Tranchida, Z. Rakotoniaina, L. Shintu, L. Tchiakpe, V. Deyris, M. Yemloul, P. Stocker, N. Vidal, O. Rimet, Abel Hiol, S. Caldarelli (2017)
Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed ratsScientific Reports, 7
A. Vasiljević, Biljana Bursać, A. Djordjevic, D. Milutinović, M. Nikolic, G. Matić, N. Veličković (2014)
Hepatic inflammation induced by high-fructose diet is associated with altered 11βHSD1 expression in the liver of Wistar ratsEuropean Journal of Nutrition, 53
H. Chen, T. Tsai, Y. Tsai, J. Liao, C. Yen, C. Yen, Chuan‐Mu Chen (2016)
Kefir peptides prevent high-fructose corn syrup-induced non-alcoholic fatty liver disease in a murine model by modulation of inflammation and the JAK2 signaling pathwayNutrition & Diabetes, 6
J. Folch, M. Lees, G. Stanley (1957)
A simple method for the isolation and purification of total lipides from animal tissues.The Journal of biological chemistry, 226 1
Biljana Bursać, A. Djordjevic, A. Vasiljević, D. Milutinović, N. Veličković, N. Nestorović, G. Matić (2013)
Fructose consumption enhances glucocorticoid action in rat visceral adipose tissue.The Journal of nutritional biochemistry, 24 6
Yi Zhang, Michael Woodruff, Ying Zhang, J. Miao, G. Hanley, C. Stuart, X. Zeng, S. Prabhakar, J. Moorman, Baoxiang Zhao, D. Yin (2008)
Toll-like receptor 4 mediates chronic restraint stress-induced immune suppressionJournal of Neuroimmunology, 194
S. Ghosh, M. May, E. Kopp (1998)
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.Annual review of immunology, 16
A. Gugliucci (2016)
Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance.Medical hypotheses, 93
Fábio Lira, José Rosa, A. Yamashita, C. Koyama, Miguel Batista, Marília Seelaender (2009)
Endurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue.Cytokine, 45 2
Zhonge Chen, Rong Yu, Y. Xiong, Fangteng Du, Shuishan Zhu (2017)
A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver diseaseLipids in Health and Disease, 16
X Cao, JN Miner, R Terkeltaub, R Liu-Bryan (2016)
Fructose amplifies inflammatory potential in human monocytic cells via reduction of AMP-activated protein kinase activityArthritis Rheumatol, 68
Amy Packard, Sriparna Ghosal, J. Herman, S. Woods, Y. Ulrich‐Lai (2014)
Chronic variable stress improves glucose tolerance in rats with sucrose-induced prediabetesPsychoneuroendocrinology, 47
S. Petrovic, A. Arsic, M. Glibetić, Nikola Čikiriz, V. Jakovljevic, V. Vučić (2016)
The effects of polyphenol-rich chokeberry juice on fatty acid profiles and lipid peroxidation of active handball players: results from a randomized, double-blind, placebo-controlled study.Canadian journal of physiology and pharmacology, 94 10
A. Salminen, J. Hyttinen, K. Kaarniranta (2011)
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespanJournal of Molecular Medicine (Berlin, Germany), 89
Biljana Bursać, A. Djordjevic, N. Veličković, D. Milutinović, S. Petrovic, Ana Teofilović, Ljupka Gligorovska, F. Preitner, L. Tappy, G. Matić (2018)
Involvement of glucocorticoid prereceptor metabolism and signaling in rat visceral adipose tissue lipid metabolism after chronic stress combined with high-fructose dietMolecular and Cellular Endocrinology, 476
S. Wagnerberger, Astrid Spruss, Giridhar Kanuri, V. Volynets, Carolin Stahl, S. Bischoff, I. Bergheim (2012)
Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis.The British journal of nutrition, 107 12
Xian Zhang, Jian-hua Zhang, Xu-Yang Chen, Qing-Hua Hu, Ming-Xing Wang, R. Jin, Qing-Yu Zhang, Wei Wang, Rong Wang, Lin-Lin Kang, Jin-sheng Li, Meng Li, Ying Pan, Jun-Jian Huang, L. Kong (2015)
Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation.Antioxidants & redox signaling, 22 10
G. Solinas, M. Karin (2010)
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunctionThe FASEB Journal, 24
Hyun Koo, Michio Miyashita, Michio Miyashita, B. Cho, Manabu Nakamura (2009)
Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus.Biochemical and biophysical research communications, 390 2
T Spector (1978)
Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50microgram of proteinAnal Biochem, 86
T. Spector (1978)
Refinement of the Coomassie blue method of protein quantitation: A simple and linear spectrophotometric assay for ≤0.5 to 50 μg of proteinAnalytical Biochemistry, 86
J. Kiecolt-Glaser (2010)
Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge.Psychosomatic medicine, 72 4
Samir Softic, Samir Softic, Manoj Gupta, Guoxiao Wang, S. Fujisaka, S. Fujisaka, T. O'neillBrian, T. O'neillBrian, Tata Rao, Tata Rao, J. Willoughby, Carole Harbison, K. Fitzgerald, O. Ilkayeva, C. Newgard, David Cohen, C. Kahn (2017)
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signalingJournal of Clinical Investigation, 127
I. Lozano, Remmelt Werf, W. Bietiger, E. Seyfritz, C. Péronet, M. Pinget, N. Jeandidier, E. Maillard, E. Marchioni, S. Sigrist, S. Dal (2016)
High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complicationsNutrition & Metabolism, 13
Hongming Miao, Yang Zhang, Zhongyan Lu, Qin Liu, Lixia Gan (2012)
FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytesInflammation Research, 61
Lydia Kuo, J. Kitlińska, Jason Tilan, Lijun Li, S. Baker, Michael Johnson, E. Lee, M. Burnett, S. Fricke, R. Květňanský, H. Herzog, Z. Żukowska (2007)
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndromeNature Medicine, 13
I. Leclercq, Valérie Lebrun, P. Stärkel, Y. Horsmans (2007)
Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARγ agonist pioglitazoneLaboratory Investigation, 87
S. Mancini, Anna White, S. Bijland, C. Rutherford, D. Graham, E. Richter, B. Viollet, R. Touyz, T. Palmer, I. Salt (2017)
Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylationMolecular and Cellular Endocrinology, 440
Xiao-Dong Yang, E. Tajkhorshid, Lin-Feng Chen (2010)
Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-κBMolecular and Cellular Biology, 30
P. Havel (2005)
Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.Nutrition reviews, 63 5
M. Lima, L. Leite, C. Gioda, F. Leme, C. Couto, C. Coimbra, V. Leite, T. Ferrari (2015)
A Novel Wistar Rat Model of Obesity-Related Nonalcoholic Fatty Liver Disease Induced by Sucrose-Rich DietJournal of Diabetes Research, 2016
N. Veličković, A. Djordjevic, A. Vasiljević, Biljana Bursać, D. Milutinović, G. Matić (2013)
Tissue-specific regulation of inflammation by macrophage migration inhibitory factor and glucocorticoids in fructose-fed Wistar ratsBritish Journal of Nutrition, 110
S. Monteiro, Susana Roque, D. Sá-Calçada, N. Sousa, M. Correia-Neves, J. Cerqueira (2015)
An Efficient Chronic Unpredictable Stress Protocol to Induce Stress-Related Responses in C57BL/6 MiceFrontiers in Psychiatry, 6
T. Kawasaki, Kanji Igarashi, Tatsuki Koeda, Keiichiro Sugimoto, Kazuya Nakagawa, S. Hayashi, R. Yamaji, H. Inui, T. Fukusato, T. Yamanouchi (2009)
Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis.The Journal of nutrition, 139 11
Jing Pang, Chao Xi, Xiu-qing Huang, J. Cui, H. Gong, Tiemei Zhang (2016)
Effects of Excess Energy Intake on Glucose and Lipid Metabolism in C57BL/6 MicePLoS ONE, 11
Anna Dittrich, Christina Khouri, S. Sackett, C. Ehlting, O. Böhmer, U. Albrecht, J. Bode, C. Trautwein, F. Schaper (2012)
Glucocorticoids increase interleukin‐6–dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitorHepatology, 55
Maria Rodrigues, M. Bekhbat, M. Houser, Jianjun Chang, D. Walker, Dean Jones, C. Nascimento, C. Barnum, M. Tansey (2017)
Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in miceBrain, Behavior, and Immunity, 59
K. Livak, Thomas Schmittgen (2001)
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.Methods, 25 4
Cuihua Zhao, Y. Zhang, Hongyang Liu, Peng Li, Han Zhang, G. Cheng (2017)
Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.Biochemical and biophysical research communications, 490 2
J. Lambertz, S. Weiskirchen, Silvano Landert, R. Weiskirchen (2017)
Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver DiseaseFrontiers in Immunology, 8
L. Axelsen, Jacob Lademann, J. Petersen, N. Holstein-Rathlou, T. Ploug, C. Prats, H. Pedersen, A. Kjølbye (2010)
Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation.American journal of physiology. Regulatory, integrative and comparative physiology, 298 6
C. Glaser, H. Demmelmair, B. Koletzko (2010)
High-Throughput Analysis of Total Plasma Fatty Acid Composition with Direct In Situ TransesterificationPLoS ONE, 5
H. Ko, Zhiyou Zhang, D. Jung, J. Jun, Zhexi Ma, Kelly Jones, Sook Chan, Jason Kim (2009)
Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the HeartDiabetes, 58
D. Schmidt-Arras, S. Rose-John (2016)
IL-6 pathway in the liver: From physiopathology to therapy.Journal of hepatology, 64 6
M. Joëls, H. Karst, D. Alfarez, V. Heine, Yongjun Qin, E. Riel, M. Verkuyl, P. Lucassen, H. Krugers (2004)
Effects of Chronic Stress on Structure and Cell Function in Rat Hippocampus and HypothalamusStress, 7
D. Carling, C. Thornton, A. Woods, M. Sanders (2012)
AMP-activated protein kinase: new regulation, new roles?The Biochemical journal, 445 1
E. Ventura, Jaimie Davis, M. Goran (2011)
Sugar Content of Popular Sweetened Beverages Based on Objective Laboratory Analysis: Focus on Fructose ContentObesity, 19
A. Vasiljević, N. Veličković, Biljana Bursać, A. Djordjevic, D. Milutinović, N. Nestorović, G. Matić (2013)
Enhanced prereceptor glucocorticoid metabolism and lipogenesis impair insulin signaling in the liver of fructose-fed rats.The Journal of nutritional biochemistry, 24 11
N. Ruderman, D. Carling, M. Prentki, José Cacicedo (2013)
AMPK, insulin resistance, and the metabolic syndrome.The Journal of clinical investigation, 123 7
Elke Bess, B. Fisslthaler, Timo Frömel, I. Fleming (2011)
Nitric Oxide-Induced Activation of the AMP-Activated Protein Kinase α2 Subunit Attenuates IκB Kinase Activity and Inflammatory Responses in Endothelial CellsPLoS ONE, 6
H. Kim, K. Park, Eun-Kyung Yoo, Y. Kim, Yoon-Nyun Kim, Hye-Soon Kim, Hyoung-Tae Kim, J. Park, Ki‐Up Lee, W. Jang, Jung‐Guk Kim, Bo-Wan Kim, In-kyu Lee (2006)
Effects of PGC-1α on TNF-α–Induced MCP-1 and VCAM-1 Expression and NF-κB Activation in Human Aortic Smooth Muscle and Endothelial CellsAntioxidants & Redox Signaling, 9
YH Yau (2013)
255Minerva Endocrinol, 38
M. McBurney, K. Clark-Knowles, Annabelle Caron, D. Gray (2013)
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.Genes & cancer, 4 3-4
Gemma Sangüesa, Miguel Baena, N. Hutter, J. Montañés, R. Sánchez, N. Roglans, J. Laguna, M. Alegret (2017)
The Addition of Liquid Fructose to a Western-Type Diet in LDL-R−/− Mice Induces Liver Inflammation and Fibrogenesis Markers without Disrupting Insulin Receptor Signalling after an Insulin ChallengeNutrients, 9
N. Roglans, L. Vilà, M. Farré, M. Alegret, R. Sánchez, M. Vázquez-Carrera, J. Laguna (2007)
Impairment of hepatic Stat‐3 activation and reduction of PPARα activity in fructose‐fed ratsHepatology, 45
J. Andrade, J. Quinn, Richad Becker, M. Shupnik (2013)
AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription.Molecular endocrinology, 27 5
M. Gauthier, Elena O’Brien, S. Bigornia, Melanie Mott, José Cacicedo, X. Xu, N. Gokce, C. Apovian, N. Ruderman (2011)
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans.Biochemical and biophysical research communications, 404 1
P. Caton, N. Nayuni, N. Khan, E. Wood, R. Corder (2011)
Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism.The Journal of endocrinology, 208 3
C. Pereira, M. Severo, D. Neves, A. Ascensão, J. Magalhães, J. Guimarães, R. Monteiro, M. Martins (2015)
Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndromeHormone Molecular Biology and Clinical Investigation, 21
Yvonne Yau, M. Potenza (2013)
Stress and eating behaviors.Minerva endocrinologica, 38 3
Y. Lee, J. Giraud, R. Davis, M. White (2003)
c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade*The Journal of Biological Chemistry, 278
Miguel Baena, Gemma Sangüesa, A. Dávalos, M. Latasa, A. Sala-Vila, R. Sánchez, N. Roglans, J. Laguna, M. Alegret (2016)
Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissuesScientific Reports, 6
P. Jiao, Bin Feng, Yujie Li, Qin He, Haiyan Xu (2013)
Hepatic ERK activity plays a role in energy metabolismMolecular and Cellular Endocrinology, 375
I. Macedo, L. Medeiros, Cleverson Oliveira, C. Oliveira, J. Rozisky, V. Scarabelot, A. Souza, Fernanda Silva, V. Santos, S. Cioato, W. Caumo, I. Torres (2012)
Cafeteria diet-induced obesity plus chronic stress alter serum leptin levelsPeptides, 38
Christophe Beauloye, Anne-Sophie Marsin, L. Bertrand, U. Krause, D. Hardie, J. Vanoverschelde, L. Hue (2001)
Insulin antagonizes AMP‐activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotidesFEBS Letters, 505
P. Dandona, A. Aljada, A. Bandyopadhyay (2004)
Inflammation: the link between insulin resistance, obesity and diabetes.Trends in immunology, 25 1
M. Dekker, Qiaozhu Su, Christopher Baker, A. Rutledge, K. Adeli (2010)
Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome.American journal of physiology. Endocrinology and metabolism, 299 5
L. Borovikova, S. Ivanova, Minghuang Zhang, Huan Yang, G. Botchkina, L. Watkins, Haichao Wang, N. Abumrad, J. Eaton, K. Tracey (2000)
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxinNature, 405
C. Lyons, E. Kennedy, H. Roche (2016)
Metabolic Inflammation-Differential Modulation by Dietary ConstituentsNutrients, 8
Qingqing Liu, M. Gauthier, Lei Sun, N. Ruderman, H. Lodish (2010)
Activation of AMP‐activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl‐CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratioThe FASEB Journal, 24
Abigail Thompson, Sarah Fourman, Amy Packard, Ann Egan, K. Ryan, Y. Ulrich‐Lai (2015)
Metabolic consequences of chronic intermittent mild stress exposurePhysiology & Behavior, 150
Purpose High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resist- ance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized as mediator between nutrient-induced stress and inflammation. Thus, we analyzed the effects of high-fructose diet, alone or in combina - tion with chronic stress, on glucose homeostasis, inflammation and expression of energy sensing proteins in the rat liver. Methods In male Wistar rats exposed to 9-week 20% fructose diet and/or 4-week chronic unpredictable stress we measured plasma and hepatic corticosterone level, indicators of glucose homeostasis and lipid metabolism, hepatic inflammation (pro- and anti-inflammatory cytokine levels, Toll-like receptor 4, NLRP3, activation of NFκB, JNK and ERK pathways) and levels of energy-sensing proteins AMPK, SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α). Results High-fructose diet led to glucose intolerance, activation of NFκB and JNK pathways and increased intrahepatic IL-1β, TNFα and inhibitory phosphorylation of insulin receptor substrate 1 on Ser . It also decreased phospho-AMPK/ AMPK ratio and increased SIRT1 expression. Stress alone increased plasma and hepatic corticosterone but did not influence glucose tolerance, nor hepatic inflammatory or energy-sensing proteins. After the combined treatment, hepatic corticosterone was increased, glucose tolerance remained preserved,
European Journal of Nutrition – Springer Journals
Published: May 29, 2018
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