Modification of liposome surface with pH-responsive polyampholytes for the controlled-release of drugs

Modification of liposome surface with pH-responsive polyampholytes for the controlled-release of... Ampholytic polymers comprised of 2-(diethylamino)ethyl methacrylate (DEAEMA) and acrylic acid (AA) in varying molar ratios were used to modify egg yolk phosphatidylcholine (EYPC) liposomes previously encapsulated with pyranine. The modified EYPC liposomes were found to be pH responsive. The critical pH values at which the pyranine release from these liposomes at 37 °C were observed to decrease with increasing DEAEMA content in the polymers. Explanations were given for these phenomena. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Modification of liposome surface with pH-responsive polyampholytes for the controlled-release of drugs

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Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer Science+Business Media BV
Subject
Chemistry; Inorganic Chemistry ; Physical Chemistry ; Catalysis
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-009-0089-6
Publisher site
See Article on Publisher Site

Abstract

Ampholytic polymers comprised of 2-(diethylamino)ethyl methacrylate (DEAEMA) and acrylic acid (AA) in varying molar ratios were used to modify egg yolk phosphatidylcholine (EYPC) liposomes previously encapsulated with pyranine. The modified EYPC liposomes were found to be pH responsive. The critical pH values at which the pyranine release from these liposomes at 37 °C were observed to decrease with increasing DEAEMA content in the polymers. Explanations were given for these phenomena.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 14, 2009

References

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