Models for prediction and recognition of eukaryotic promoters

Models for prediction and recognition of eukaryotic promoters Mammalian Genome 10, 168–175 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Thomas Werner GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolsta ¨dter Landstrabe 1, D-85764 Neuherberg, and Genomatix Software GmbH, Karlstrabe 55, D-80333 Mu ¨ nchen, Germany Received: 21 July 1998 / Accepted: 7 October 1998 Introduction functionality of a promoter would also be welcome for gene therapy approaches to improve expression of newly created vector The enormous impact of various genome sequencing projects is constructs. bringing the importance of computer-assisted nucleotide sequence analysis to the attention of a constantly increasing number of sci- Transcriptional promoters and their functions entists. Gene prediction is undoubtedly leading the list of impor- tant tasks in this context. It is also generally accepted that this task consists of the recognition of the exon/intron structure of the cod- All attempts to predict promoters necessarily include a model of ing region as well as prediction of the corresponding promoter. how a promoter is organized or what the hallmarks of a promoter However, there is much less agreement about the exact sequences are. The strong as well as the weak points of different methods for that should be called http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Models for prediction and recognition of eukaryotic promoters

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Publisher
Springer Journals
Copyright
Copyright © 1999 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900963
Publisher site
See Article on Publisher Site

Abstract

Mammalian Genome 10, 168–175 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Thomas Werner GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolsta ¨dter Landstrabe 1, D-85764 Neuherberg, and Genomatix Software GmbH, Karlstrabe 55, D-80333 Mu ¨ nchen, Germany Received: 21 July 1998 / Accepted: 7 October 1998 Introduction functionality of a promoter would also be welcome for gene therapy approaches to improve expression of newly created vector The enormous impact of various genome sequencing projects is constructs. bringing the importance of computer-assisted nucleotide sequence analysis to the attention of a constantly increasing number of sci- Transcriptional promoters and their functions entists. Gene prediction is undoubtedly leading the list of impor- tant tasks in this context. It is also generally accepted that this task consists of the recognition of the exon/intron structure of the cod- All attempts to predict promoters necessarily include a model of ing region as well as prediction of the corresponding promoter. how a promoter is organized or what the hallmarks of a promoter However, there is much less agreement about the exact sequences are. The strong as well as the weak points of different methods for that should be called

Journal

Mammalian GenomeSpringer Journals

Published: Feb 1, 1999

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