Modelomics to Investigate Cancer Bone Metastasis

Modelomics to Investigate Cancer Bone Metastasis Purpose of review Modelomics approach allows modelling and understanding of the mechanisms regulating living complex systems using computational and experimental models. Here, our aim was to highlight recent cancer models with the focus on bioengineering tool box to study bone metastasis cascade. Recent findings Bone is a common site for cancer metastasis. In the last few decades, various in vitro and in vivo models have been used to provide insights into the treatment of human cancer bone metastasis. Despite significant advances into the under- standing of molecular and cellular mechanisms of cancer bone metastasis using traditional models, recent studies reported the functional failure of the new drugs when tested in humans and demonstrated the inability of current bone metastasis models to mimic corresponding human disease. The failure of cancer treatments highlights the importance of reviewing the efficiency and efficacy of current modelomics to accurately investigate bone metastasis. Summary Development of innovative cancer bone metastasis models is an essential step to develop new therapies or investigate the feasibility of current treatments. The emergence of bone on chip, tissue engineering of humanized mouse models has the potential to overcome the limitation of current platforms by better recapitulation of the cancer bone http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Molecular Biology Reports Springer Journals

Modelomics to Investigate Cancer Bone Metastasis

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Molecular Medicine; Human Genetics
eISSN
2198-6428
D.O.I.
10.1007/s40610-018-0094-x
Publisher site
See Article on Publisher Site

Abstract

Purpose of review Modelomics approach allows modelling and understanding of the mechanisms regulating living complex systems using computational and experimental models. Here, our aim was to highlight recent cancer models with the focus on bioengineering tool box to study bone metastasis cascade. Recent findings Bone is a common site for cancer metastasis. In the last few decades, various in vitro and in vivo models have been used to provide insights into the treatment of human cancer bone metastasis. Despite significant advances into the under- standing of molecular and cellular mechanisms of cancer bone metastasis using traditional models, recent studies reported the functional failure of the new drugs when tested in humans and demonstrated the inability of current bone metastasis models to mimic corresponding human disease. The failure of cancer treatments highlights the importance of reviewing the efficiency and efficacy of current modelomics to accurately investigate bone metastasis. Summary Development of innovative cancer bone metastasis models is an essential step to develop new therapies or investigate the feasibility of current treatments. The emergence of bone on chip, tissue engineering of humanized mouse models has the potential to overcome the limitation of current platforms by better recapitulation of the cancer bone

Journal

Current Molecular Biology ReportsSpringer Journals

Published: Apr 23, 2018

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