Modeling of Periodically Changing Predictable Response to Mutagens in Successive Inbred Generations of CBA/LacY Mice

Modeling of Periodically Changing Predictable Response to Mutagens in Successive Inbred... A hypothesis on the genetic determination of periodic fluctuations of the sensitivity to the mutagen thioTEPA in successive inbred generations of mice has been earlier put forward. This study was the initial stage of testing this hypothesis. The mouse strain CBA/LacY was divided into two substrains, which differed in the rate of generation change. As a result, two colonies of isogenic mice differing by 10–12 generations with respect to the inbred age will be obtained. Both the rate and range of variations in the mutagen sensitivity (four generations per period of the cycle and 20–40% of cells with chromosome aberrations after the standard dose of 2.5 mg/kg of thioTEPA, respectively) in 19 generations of the “fast” substrain agreed with earlier data. The response of the “slow” substrain corresponded to the expected response of the “fast” substrain after the given number of generations. In the mice of generations F142and F146that lived simultaneously and differed in thioTEPA sensitivity, the effects of the carcinogen benzo[a]pyrene (BaP) were significantly different. The levels of these effects corresponded to the levels of the responses to thioTEPA. The data obtained agree with the hypothesis tested. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Modeling of Periodically Changing Predictable Response to Mutagens in Successive Inbred Generations of CBA/LacY Mice

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1012348420473
Publisher site
See Article on Publisher Site

Abstract

A hypothesis on the genetic determination of periodic fluctuations of the sensitivity to the mutagen thioTEPA in successive inbred generations of mice has been earlier put forward. This study was the initial stage of testing this hypothesis. The mouse strain CBA/LacY was divided into two substrains, which differed in the rate of generation change. As a result, two colonies of isogenic mice differing by 10–12 generations with respect to the inbred age will be obtained. Both the rate and range of variations in the mutagen sensitivity (four generations per period of the cycle and 20–40% of cells with chromosome aberrations after the standard dose of 2.5 mg/kg of thioTEPA, respectively) in 19 generations of the “fast” substrain agreed with earlier data. The response of the “slow” substrain corresponded to the expected response of the “fast” substrain after the given number of generations. In the mice of generations F142and F146that lived simultaneously and differed in thioTEPA sensitivity, the effects of the carcinogen benzo[a]pyrene (BaP) were significantly different. The levels of these effects corresponded to the levels of the responses to thioTEPA. The data obtained agree with the hypothesis tested.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 16, 2004

References

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