Mobile Genetic Element gypsy(MDG4) in Drosophila melanogasterStrains: Structural Characteristics and Regulation of Transposition

Mobile Genetic Element gypsy(MDG4) in Drosophila melanogasterStrains: Structural Characteristics... Distribution of two structural functional variants of the gypsy(MDG4) mobile genetic element was examined in 44 strains of Drosophila melenogaster. The results obtained suggest that less transpositionally active gypsyvariant is more ancient component of the Drosophilagenome. Using Southern blotting, five strains characterized by increased copy number of gypsywith significant prevalence of the active variant over the less active one were selected for further analysis. Genetic analysis of these strains led to the suggestion that some of them carry factors that mobilize gypsyindependently from the cellular flamencogene known to be responsible for transposition of this element. Other strains probably contained a suppressor of the flam –mutant allele causing active transpositions of the gypsy. Thus, the material for studying poorly examined relationships between the retrovirus and the host cell genome was obtained. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Mobile Genetic Element gypsy(MDG4) in Drosophila melanogasterStrains: Structural Characteristics and Regulation of Transposition

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1013287909186
Publisher site
See Article on Publisher Site

Abstract

Distribution of two structural functional variants of the gypsy(MDG4) mobile genetic element was examined in 44 strains of Drosophila melenogaster. The results obtained suggest that less transpositionally active gypsyvariant is more ancient component of the Drosophilagenome. Using Southern blotting, five strains characterized by increased copy number of gypsywith significant prevalence of the active variant over the less active one were selected for further analysis. Genetic analysis of these strains led to the suggestion that some of them carry factors that mobilize gypsyindependently from the cellular flamencogene known to be responsible for transposition of this element. Other strains probably contained a suppressor of the flam –mutant allele causing active transpositions of the gypsy. Thus, the material for studying poorly examined relationships between the retrovirus and the host cell genome was obtained.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 16, 2004

References

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