Psychiatric Quarterly [psaq] PH246-psaq-478276 February 20, 2004 18:2 Style ﬁle version June 4th, 2002
Psychiatric Quarterly, Vol. 75, No. 2, Summer 2004 (
MIXED VERSUS MANIC BIPOLAR
DISORDER: A COMPARISON
OF DEMOGRAPHIC, SYMPTOMATIC,
AND TREATMENT DIFFERENCES
Nurun N. Shah, M.D., Patricia M. Averill, Ph.D.,
and Andrew Shack, Ph.D.
This study compared patients diagnosed with Mixed versus Manic Bipolar dis-
order across the domains of demographic, symptom, and treatment variables.
The sample included 152 patients who were admitted to an acute care psy-
chiatric facility within an index period, whose discharge diagnosis was either
Bipolar Disorder, Manic Episode (n = 109) or Bipolar Disorder, Mixed Episode
(n= 43). No signiﬁcant differences were found in age, race, episode number, or
length of stay. There was a trend toward females being diagnosed with a Mixed
Episode and males a Manic Episode. Group differences were found on physician
and nurse symptom ratings, with the manic group receiving higher ratings on
resistance, psychosis, and conceptual disorganization and the mixed receiving
higher scores on depression and anxiety. On self-report measures, the mixed
group endorsed greater severity than did the manic group. The mixed group
was more likely to be prescribed antidepressants at discharge; however there
All authors are afﬁliated with Department of Psychiatry and Behavioral Sciences,
University of Texas – Houston, Harris County Psychiatric Center, Houston, TX.
Address correspondence to Nurun N. Shah, M.D., University of Texas – Houston,
Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021,
2004 Human Sciences Press, Inc.