Mitochondrial mRNA expression in fibroblasts of Down syndrome subjects

Mitochondrial mRNA expression in fibroblasts of Down syndrome subjects Human Cell (2018) 31:179–181 https://doi.org/10.1007/s13577-018-0205-2 LE T TER TO  THE   EDITOR Mitochondrial mRNA expression in fibroblasts of Down syndrome subjects 1 1 1 1 1 Michele Salemi  · Mariaconcetta Giambirtone  · Concetta Barone  · Maria Grazia Salluzzo  · Roberto Russo  · 1 1 2 1 Mariangela Lo Giudice  · Salvatore Cutuli  · Federico Ridolfo  · Corrado Romano Received: 19 December 2017 / Accepted: 21 February 2018 / Published online: 3 March 2018 © Japan Human Cell Society and Springer Japan KK, part of Springer Nature 2018 Dear Sir, Complex IV or cytochrome c oxidase is located within mitochondrial inner membrane and is the third and final In Wong’s article it was highlighted that mitochondrial enzyme of electron transport chain of mitochondrial oxida- activity disregulation may affect early onset of Alzheimer’s tive phosphorylation. There are 3 subunits of complex IV in subjects with Down syndrome (DS) [1]. (OMIM 516030) encoded by mtDNA: CO1, CO2 and CO3. From this study, we have taken the lead to evaluate the Complex V (ATP synthase) is a ubiquitous membrane expression of the various mitochondrial subunits in subjects enzyme that plays a key role in biological energy metab- with DS. olism. ATP synthase comprises 2 subunits encoded by Trisomy 21 or Down syndrome is caused by the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Cell Springer Journals
Loading next page...
 
/lp/springer_journal/mitochondrial-mrna-expression-in-fibroblasts-of-down-syndrome-subjects-z1lrJ3FWmz
Publisher
Springer Japan
Copyright
Copyright © 2018 by Japan Human Cell Society and Springer Japan KK, part of Springer Nature
Subject
Life Sciences; Cell Biology; Embryology; Oncology; Stem Cells; Reproductive Medicine; Cell Culture
eISSN
1749-0774
D.O.I.
10.1007/s13577-018-0205-2
Publisher site
See Article on Publisher Site

Abstract

Human Cell (2018) 31:179–181 https://doi.org/10.1007/s13577-018-0205-2 LE T TER TO  THE   EDITOR Mitochondrial mRNA expression in fibroblasts of Down syndrome subjects 1 1 1 1 1 Michele Salemi  · Mariaconcetta Giambirtone  · Concetta Barone  · Maria Grazia Salluzzo  · Roberto Russo  · 1 1 2 1 Mariangela Lo Giudice  · Salvatore Cutuli  · Federico Ridolfo  · Corrado Romano Received: 19 December 2017 / Accepted: 21 February 2018 / Published online: 3 March 2018 © Japan Human Cell Society and Springer Japan KK, part of Springer Nature 2018 Dear Sir, Complex IV or cytochrome c oxidase is located within mitochondrial inner membrane and is the third and final In Wong’s article it was highlighted that mitochondrial enzyme of electron transport chain of mitochondrial oxida- activity disregulation may affect early onset of Alzheimer’s tive phosphorylation. There are 3 subunits of complex IV in subjects with Down syndrome (DS) [1]. (OMIM 516030) encoded by mtDNA: CO1, CO2 and CO3. From this study, we have taken the lead to evaluate the Complex V (ATP synthase) is a ubiquitous membrane expression of the various mitochondrial subunits in subjects enzyme that plays a key role in biological energy metab- with DS. olism. ATP synthase comprises 2 subunits encoded by Trisomy 21 or Down syndrome is caused by the

Journal

Human CellSpringer Journals

Published: Mar 3, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off