Human Cell (2018) 31:179–181 https://doi.org/10.1007/s13577-018-0205-2 LE T TER TO THE EDITOR Mitochondrial mRNA expression in fibroblasts of Down syndrome subjects 1 1 1 1 1 Michele Salemi · Mariaconcetta Giambirtone · Concetta Barone · Maria Grazia Salluzzo · Roberto Russo · 1 1 2 1 Mariangela Lo Giudice · Salvatore Cutuli · Federico Ridolfo · Corrado Romano Received: 19 December 2017 / Accepted: 21 February 2018 / Published online: 3 March 2018 © Japan Human Cell Society and Springer Japan KK, part of Springer Nature 2018 Dear Sir, Complex IV or cytochrome c oxidase is located within mitochondrial inner membrane and is the third and final In Wong’s article it was highlighted that mitochondrial enzyme of electron transport chain of mitochondrial oxida- activity disregulation may affect early onset of Alzheimer’s tive phosphorylation. There are 3 subunits of complex IV in subjects with Down syndrome (DS) . (OMIM 516030) encoded by mtDNA: CO1, CO2 and CO3. From this study, we have taken the lead to evaluate the Complex V (ATP synthase) is a ubiquitous membrane expression of the various mitochondrial subunits in subjects enzyme that plays a key role in biological energy metab- with DS. olism. ATP synthase comprises 2 subunits encoded by Trisomy 21 or Down syndrome is caused by the
Human Cell – Springer Journals
Published: Mar 3, 2018
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