Drugs https://doi.org/10.1007/s40265-018-0924-4 ADIS DRUG EVALUATION Emma D. Deeks Springer International Publishing AG, part of Springer Nature 2018 Abstract The ﬁrst-in-class b -adrenoceptor agonist mir- status, although data in men (from a phase 4 study and TM abegron is indicated in the EU (Betmiga ), Japan (Be- phase 3 trial subanalyses) are variable; additional studies in TM tanis ) and several other countries for the management of older and male OAB patients are awaited with interest. overactive bladder (OAB) syndrome. Evidence for its use Although further longer-term efﬁcacy and tolerability data in this setting includes several large phase 3 trials. Com- would be beneﬁcial, current clinical evidence indicates that pared with placebo, oral mirabegron for 12 weeks reduced mirabegron provides an alternative to antimuscarinics for the frequency of micturition and generally also that of the management of OAB in adults, including those for incontinence, with other beneﬁts including reduced whom antimuscarinics have proven unsuitable. urgency, increased void volume and improved health related quality-of-life (HR-QOL). Mirabegron comparisons versus tolterodine are descriptive; however, in a 12-week Mirabegron: clinical considerations in OAB powered comparison versus solifenacin in patients dissat- isﬁed with antimuscarinic efﬁcacy, mirabegron did not First b -adrenoceptor agonist approved for OAB
Drugs – Springer Journals
Published: Jun 4, 2018
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