Breast Cancer (2017) 24:673–682 DOI 10.1007/s12282-017-0756-1 ORIGINAL ARTICLE miR-668 enhances the radioresistance of human breast cancer cell by targeting IjBa 1,2 1,2 1,2 1,2,3 • • • Ming Luo Ling Ding Qingjian Li Herui Yao Received: 5 September 2016 / Accepted: 18 January 2017 / Published online: 30 January 2017 The Japanese Breast Cancer Society 2017 Abstract IjBa expression, suppressed NF-jB, increased radiosen- Background A large proportion of breast cancer patients sitivity of MCF-7R and T-47DR cells. are resistant to radiotherapy, which is a mainstay treatment Conclusion Our ﬁndings suggest miR-668 is involved in for this malignancy, but the mechanisms of radioresistance the radioresistance of breast cancer cells and miR-668- remain unclear. IjBa-NF-jB axis may be a novel candidate for developing Methods and materials To evaluate the role of miRNAs in rational therapeutic strategies for human breast cancer radioresistance, we established two radioresistant breast treatment. cancer cell lines MCF-7R and T-47DR derived from par- ental MCF-7 and T-47D. Moreover, miRNA microarray, Keywords miR-668 Radioresistance Breast cancer quantitative RT-PCR analysis, luciferase reporter assay and IjBa NF-jB western blotting were used. Results We found that miR-668 was most abundantly expressed in radioresistant cells MCF-7R and T-47DR. Introduction miR-668
Breast Cancer – Springer Journals
Published: Jan 30, 2017
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