J Mol Med (2017) 95:977–993 DOI 10.1007/s00109-017-1541-5 ORIGINAL ARTICLE MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling 1 2 2 2 2 Cui Ma & Chen Zhang & Mingfei Ma & Lixin Zhang & Linlin Zhang & 2 1 3 4 4 Fengying Zhang & Yingli Chen & Fangyuan Cao & Minghui Li & Guangtian Wang & 2 2 1 4 2 Tingting Shen & Hongmin Yao & Yumei Liu & Zhenwei Pan & Shasha Song & 2,4,5,6,7 Daling Zhu Received: 17 August 2016 /Revised: 14 March 2017 /Accepted: 28 April 2017 /Published online: 7 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract as well as hypoxia-stimulated cell-cycle transition from the G / Abnormal pulmonary arterial smooth muscle cells (PASMCs) G phase to S phase. Subsequently, we studied the role of proliferation is an important pathological process in hypoxic microRNAs in mitochondrial function associated with pulmonary arterial hypertension. Mitochondrial dynamics and PASMC proliferation under hypoxic conditions. The promotive quality control have a central role in the maintenance of the cell effect of Mfn1 on pulmonary vascular remodeling was allevi- proliferation–apoptosis balance. However, the molecular mech- ated in the presence of miR-125a agomir, and miR-125a
Journal of Molecular Medicine – Springer Journals
Published: Jun 7, 2017
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