Reactions 1704, p251 - 2 Jun 2018 Sinus node dysfunction accompanied by syncope: case report A 9-year-old girl developed sinus node dysfunction accompanied by syncope during treatment with minoxidil for alopecia [dosage and duration of treatment to reaction onset not stated]. The girl had been applying topical minoxidil for alopecia for two years. She presented for cardiac assessment before starting systemic minoxidil. She reported syncope once upon giving blood. She underwent cardiac monitoring for 24 hours using Holter monitor and asystolic attacks and sinus arrest were noted lasting for 4–6 seconds, accompanied by one episode of syncope in the morning hours. The girl’s treatment with minoxidil was discontinued. She was hospitalized for monitoring and scheduled for permanent pacemaker implantation. Transesophageal electrophysiological study was performed. After discontinuing minoxidil, the sinus arrest and sinus node dysfunction resolved, with normal sinus node function. Later, she was closely monitored for cardiac function. Implantation of the permanent pacemaker was not performed due to morbidity in paediatrics, and she was discharged home asymptomatically. Author comment: "The sinus node dysfunction experienced in this case was categorized as likely related to minoxidil (score 5), as assessed by the Naranjo adverse drug reaction probability assessment tool." Koca S, et al. Topical minoxidil treatment and sinus node dysfunciton in a child patient. Eastern Journal of Medicine 23: 121-123, No. 2, Apr-Jun 2018. Available from: URL: http://doi.org/10.5505/ejm.2018.47955 - Turkey 803322941 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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