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Mineral oil

Mineral oil Reactions 1704, p249 - 2 Jun 2018 Various toxicities: 12 case reports In a study, 12 men aged 24 50 years were described, who developed hypercalcaemia, hypercalciuria and renal impairment following administration of mineral oil [paraffin oil] for increasing apparent muscle size. In one out of these 12 men, paraffinomas was also noted. The men received IM injection of mineral oil for increasing apparent muscle size. Of these 12 men, seven men received IM injection of mineral oil in the dose range of 100 2000mL [not all dosages stated]. After 1 8 years from injection, they were admitted to the hospitals with hypercalcaemia, hypercalciuria and renal impairment. One of these 12 men also developed paraffinomas. The men received treatment with glucocorticoids, denosumab, zoledronic acid, pamidronic acid, calcitonin [Miacalcic], azathioprine, hydroxychloroquine [Plaquinil], mycophenolate or infliximab. One out of these 12 men underwent surgery in October 2016 for removal of the paraffinomas and the paraffinomas was surgically removed. Of these 12 men, the outcome of hypercalcaemia was reported as recovered (1 patient), recovering (4 patients), not recovered (3 patients) and unknown (4 patients) [not all outcomes stated]. Author comment: "We now report a case series of 12 patients with non-parathyroid hypercalcemia http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Mineral oil

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Mineral oil

Abstract

Reactions 1704, p249 - 2 Jun 2018 Various toxicities: 12 case reports In a study, 12 men aged 24 50 years were described, who developed hypercalcaemia, hypercalciuria and renal impairment following administration of mineral oil [paraffin oil] for increasing apparent muscle size. In one out of these 12 men, paraffinomas was also noted. The men received IM injection of mineral oil for increasing apparent muscle size. Of these 12 men, seven men received IM injection of mineral oil in the dose...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46892-z
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p249 - 2 Jun 2018 Various toxicities: 12 case reports In a study, 12 men aged 24 50 years were described, who developed hypercalcaemia, hypercalciuria and renal impairment following administration of mineral oil [paraffin oil] for increasing apparent muscle size. In one out of these 12 men, paraffinomas was also noted. The men received IM injection of mineral oil for increasing apparent muscle size. Of these 12 men, seven men received IM injection of mineral oil in the dose range of 100 2000mL [not all dosages stated]. After 1 8 years from injection, they were admitted to the hospitals with hypercalcaemia, hypercalciuria and renal impairment. One of these 12 men also developed paraffinomas. The men received treatment with glucocorticoids, denosumab, zoledronic acid, pamidronic acid, calcitonin [Miacalcic], azathioprine, hydroxychloroquine [Plaquinil], mycophenolate or infliximab. One out of these 12 men underwent surgery in October 2016 for removal of the paraffinomas and the paraffinomas was surgically removed. Of these 12 men, the outcome of hypercalcaemia was reported as recovered (1 patient), recovering (4 patients), not recovered (3 patients) and unknown (4 patients) [not all outcomes stated]. Author comment: "We now report a case series of 12 patients with non-parathyroid hypercalcemia

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

References

  • Non-parathyroid hypercalcemia associated with paraffin oil injection in 12 younger male bodybuilders: a case series.
    Solling, ASK