Reactions 1704, p249 - 2 Jun 2018 Various toxicities: 12 case reports In a study, 12 men aged 24 50 years were described, who developed hypercalcaemia, hypercalciuria and renal impairment following administration of mineral oil [paraffin oil] for increasing apparent muscle size. In one out of these 12 men, paraffinomas was also noted. The men received IM injection of mineral oil for increasing apparent muscle size. Of these 12 men, seven men received IM injection of mineral oil in the dose range of 100 2000mL [not all dosages stated]. After 1 8 years from injection, they were admitted to the hospitals with hypercalcaemia, hypercalciuria and renal impairment. One of these 12 men also developed paraffinomas. The men received treatment with glucocorticoids, denosumab, zoledronic acid, pamidronic acid, calcitonin [Miacalcic], azathioprine, hydroxychloroquine [Plaquinil], mycophenolate or infliximab. One out of these 12 men underwent surgery in October 2016 for removal of the paraffinomas and the paraffinomas was surgically removed. Of these 12 men, the outcome of hypercalcaemia was reported as recovered (1 patient), recovering (4 patients), not recovered (3 patients) and unknown (4 patients) [not all outcomes stated]. Author comment: "We now report a case series of 12 patients with non-parathyroid hypercalcemia associated with intramuscular injections of paraffin oil." "In a few case reports, long-term side effects have been reported in terms of hypercalcemia and renal failure." Solling ASK, et al. Non-parathyroid hypercalcemia associated with paraffin oil injection in 12 younger male bodybuilders: a case series. European Journal of Endocrinology 178: K29-K37, No. 6, Jun 2018. Available from: URL: http:// doi.org/10.1530/EJE-18-0051 - Denmark 803322811 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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