Russian Journal of Applied Chemistry, 2013, Vol. 86, No. 5, pp. 691695.
Pleiades Publishing, Ltd., 2013.
Original Russian Text © L.A. Rasskazova, N.M. Korotchenko, G.M. Zeer, 2013, published in Zhurnal Prikladnoi Khimii, 2013, Vol. 86, No. 5, pp. 744748.
Microwave Synthesis of Hydroxyapatite
and Physicochemical Study of Its Properties
L. A. Rasskazova
, N. M. Korotchenko
, and G. M. Zeer
National Research Tomsk State University, Tomsk, Russia
Siberian Federal University, Krasnoyarsk, Russia
Received August 24, 2012
Abstract—Method for microwave liquid-phase synthesis of hydroxyapatite samples was developed. The com-
position of the synthesis products obtained and natural hydroxyapatite was studied by X-ray phase and X-ray
ﬂ uorescence microanalysis. IR spectra were measured and the dispersity of hydroxyapatite powders obtained, their
solubility in water at 20°C, and structural parameters were determined in comparison with natural hydroxyapatite
and that produced by the common (“classical”) liquid-phase technique. The microwave-synthesized hydroxyapatite
compares well in its properties with the biological and “classical” hydroxyapatites.
In all leading world’s countries and in Russia,
scientists are actively involved in the development
and studies of biologically active materials for
reconstructive osteoplastic surgery . One of materials
of this kind is hydroxyapatite (HA) Ca
Hydroxyapatite, the predominant component of
bone tissue, exhibits a unique biocompatibility and
an increased osteointegration activity. However, the
presently used natural (allogenic) HA frequently has
a number of important shortcomings associated with
infection transfer risk, accumulation of heavy metals
in bones, and high cost of such a material . In this
context, development of new accessible methods for
synthesis of an artiﬁ cial HA with properties noninferior
to those of the biological material is a topical issue.
The microwave radiation as a means of affecting
physicochemical processes in solution has recently
found rather wide application. The microwave radiation
can make tens and hundreds of times faster numerous
chemical reactions and cause fast bulk heating of liquid
and solid samples . The heating of a sample by
microwave radiation is to the interaction of the radiation
having, in many cases, a rather good penetrating capacity
with molecules (ions) over the entire volume of a
material being irradiated . As a result, heating occurs
simultaneously over the entire volume of a sample being
irradiated. The application of microwave radiation in
syntheses of numerous substances and materials based
on these substances is considered to be rather promising.
A liquid-phase synthesis of hydroxyapatite was
performed in the study at pH ~11 under microwave
irradiation in accordance with the reaction equation
In the ﬁ rst synthesis (sample 1), the starting reagents
were slowly mixed in stoichiometric amounts and
subjected to a microwave irradiation. In the second
synthesis (sample 2), the reagents were rapidly poured
together and immediately subjected to a microwave
irradiation. For comparison, sample 3 was synthesized
by the previously described conventional liquid-phase
precipitation technique .
The starting solutions were prepared from reagents