Microwave-assisted facile synthesis of trisubstituted pyrrole derivatives

Microwave-assisted facile synthesis of trisubstituted pyrrole derivatives Keywords Pyrroles  Microwave irradiation  Time saved  Ring effect Introduction In recent times, synthetic methods have been developed to save time and achieve quantitative yields. Microwave irradiation has increased in importance because of its several advantages, including experimental simplicity, reduced reaction time, lower energy requirement, improved substrate reactivity, and product formation Electronic supplementary material The online version of this article (doi:10.1007/s11164-015-1966-9) contains supplementary material, which is available to authorized users. V. Hanuman Reddy  G. Mallikarjuna Reddy  M. Thirupalu Reddy  Y. V. Rami Reddy (&) Department of Chemistry, Sri Venkateswara University, Tirupati, India e-mail: dryvrsvu@gmail.com V. Hanuman Reddy Organic Division, Indian Institute of Chemical Science, Hyderabad, Tarnaka, Hyderabad, India 123 9806 V. H. Reddy et al. efficiency, because energizing the reactions leads to almost quantitative yields. Theoretical calculations have also suggested that reactions with high activation energies can be performed under microwave irradiation without use of harsh reaction conditions. Nowadays, numerous important heterocycles have been synthesized by use of microwave irradiation [1–6]. Among five-membered heterocycles, the pyrrole core is a ubiquitous structural unit of many natural compounds, including hemoglobin, chlorophyll, vitamin B12, L-tryptophan [7, 8], alkaloids [9, 10], and numerous essential drugs [11, 12] and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Microwave-assisted facile synthesis of trisubstituted pyrrole derivatives

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Springer Netherlands
Copyright © 2015 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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